Document Detail

Outcome of pregnancy after the Mustard operation for transposition of the great arteries with intact ventricular septum.
MedLine Citation:
PMID:  8006264     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study examined the outcome of pregnancy in patients with transposition of the great arteries and an intact ventricular septum after a Mustard operation. BACKGROUND: Before the introduction of surgical treatment, most children with transposition of the great arteries died in early infancy. A number of these patients have now reached their reproductive years. There is little information about the effect of pregnancy on cardiovascular status, particularly the ability of the right ventricle to adjust to the hemodynamic changes of pregnancy. The outcome for the offspring and their risk of congenital heart disease are also unknown. METHODS: Twenty-three female late survivors after the Mustard operation > 15 years of age were reviewed in relation to the occurrence of pregnancy and its outcome. Serial echocardiographic estimates of right ventricular volume during pregnancy were made in three local patients. RESULTS: Nine women had 15 pregnancies. They were asymptomatic before pregnancy and remained free from cardiac symptoms during each pregnancy. Right ventricular volume in the three patients studied increased during pregnancy but returned to normal at 8 to 11 weeks postpartum. There were 12 live births, 2 spontaneous abortions and 1 intrauterine death. None of the liveborn infants had evidence of congenital heart disease. CONCLUSIONS: In this small group of women with good quality late survival after a Mustard operation, pregnancy was well tolerated. We suspect that the incidence of congenital heart disease in infants of mothers with transposition of the great arteries will be at the lower end of the range for mothers with different types of congenital heart disease, but further data will be needed to confirm this.
P M Clarkson; N J Wilson; J M Neutze; R A North; A L Calder; B G Barratt-Boyes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  24     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-07-20     Completed Date:  1994-07-20     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  190-3     Citation Subset:  AIM; IM    
Department of Cardiology, Green Lane Hospital, Auckland, New Zealand.
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MeSH Terms
Delivery, Obstetric
Heart Defects, Congenital / epidemiology
Infant, Newborn
New Zealand / epidemiology
Postoperative Period
Postpartum Period
Pregnancy Complications, Cardiovascular / ultrasonography*
Pregnancy Outcome* / epidemiology
Risk Factors
Transposition of Great Vessels / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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