Document Detail

Outcome of pregnancies when fathers are treated with 6-mercaptopurine for inflammatory bowel disease.
MedLine Citation:
PMID:  10710057     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The outcomes of pregnancies after maternal use of 6-mercaptopurine (6-MP) for inflammatory bowel disease (IBD) during pregnancy have been reported, but data are lacking for outcomes when the fathers use this drug. METHODS: Subjects were male patients with IBD seen at one center between 1970 and 1997. Patients and their wives were interviewed. Group 1 comprised pregnancies fathered by men who were taking 6-MP. This group was further subdivided into those conceived within 3 months of 6-MP use and those conceived at least 3 months after 6-MP was stopped. Group 2 comprised pregnancies fathered by men with IBD, similar in characteristics to group 1, who had not taken 6-MP before fertilization. Information was collected regarding the fathers, the mothers, and the pregnancies, as well as the health of the children, in a historical cohort study. RESULTS: There were 50 pregnancies in group 1 (13 in 1A and 37 in 1B) and 90 pregnancies in group 2. Four of the 13 pregnancies in group 1A were associated with complications. There were two spontaneous abortions, and two congenital anomalies including a missing thumb in one and acrania with multiple digital and limb abnormalities in the other. Risk of complications was significantly increased when compared with group 1B (p < 0.013) and group 2 (p < 0.002). CONCLUSION: The incidence of pregnancy-related complications was significantly increased when the fathers used 6-MP within 3 months of conception.
R O Rajapakse; B I Korelitz; J Zlatanic; P J Baiocco; G W Gleim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  95     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-21     Completed Date:  2000-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  684-8     Citation Subset:  IM    
Department of Medicine, Lenox Hill Hospital and New York University School of Medicine, New York 10021, USA.
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MeSH Terms
6-Mercaptopurine / adverse effects*,  therapeutic use
Abnormalities, Drug-Induced / etiology*
Drug Administration Schedule
Immunosuppressive Agents / adverse effects*,  therapeutic use
Infant, Newborn
Inflammatory Bowel Diseases / drug therapy*
Pregnancy Outcome
Reg. No./Substance:
0/Immunosuppressive Agents; 50-44-2/6-Mercaptopurine
Comment In:
Am J Gastroenterol. 2001 Jan;96(1):251   [PMID:  11197266 ]
Am J Gastroenterol. 2000 Mar;95(3):581-2   [PMID:  10710042 ]
Am J Gastroenterol. 2000 Sep;95(9):2386-7   [PMID:  11007251 ]

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