| Outcome of patients with nonsustained ventricular tachycardia and severely impaired ventricular function who have negative electrophysiologic studies. | |
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MedLine Citation:
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PMID: 7872177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-nine consecutive patients with a prior myocardial infarction, severely reduced left ventricular ejection fraction (26% +/- 8%), and asymptomatic nonsustained ventricular tachycardia were enrolled in a prospective trial. After a negative programmed electric stimulation study (3 extrastimuli at 2 sites with 2 drive trains), the 26 men and 3 women (mean age 71) were monitored for a mean of 13 months without antiarrhythmic drug therapy. Five patients died suddenly or had sustained ventricular tachycardia; three others had a cardiac, nonarrhythmic death. Events occurred in the first 13 months of the surveillance period. Clinical factors associated with a poor outcome included congestive heart failure and lack of beta-blocker therapy. In addition, patients with events tended to have lower ejection fractions than those without (21% vs 28%, p not significant). Thus a negative programmed electric stimulation study does not necessarily imply a benign outcome in patients with a prior infarction and nonsustained ventricular tachycardia if they also have severe left ventricular dysfunction and a history of heart failure. These data have important implications for the design and conduct of contemporary clinical trials. |
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Authors:
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M Hernández; J Taylor; R Marinchak; S Rials; A Rubin; P Kowey |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 129 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-03-27 Completed Date: 1995-03-27 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 492-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiovascular Diseases, Lankenau Hospital and Medical Research Center, Wynnewood, PA 19096. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease-Free Survival Electric Stimulation Electrophysiology Female Follow-Up Studies Humans Male Myocardial Infarction / complications, mortality, physiopathology* Prospective Studies Stroke Volume Survival Analysis Tachycardia, Ventricular / etiology, physiopathology* Ventricular Dysfunction, Left / complications, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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