Document Detail


Outcome of oral dysplasia: a retrospective hospital-based study of 207 patients with a long follow-up.
MedLine Citation:
PMID:  19453839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this retrospective hospital-based study was to review and evaluate the long-term outcome of patients with oral epithelial dysplasia (OED), with or without surgical intervention, to identify factors affecting clinical course and malignant evolution. Patients with a follow-up of at least 12 months were included. Data collected were statistically analyzed. The mean age was 63.58 years for women (n = 100) and 64.17 years for men (n = 107). One hundred and thirty-five of the patients had lesions with histopathological features of mild OED, 50 had moderate OED and 22 had severe OED. Gender and risk factors seemed not to be related with the development of OED. One hundred and thirty-three patients underwent active treatment. During the period considered, 39.4% of the 207 lesions disappeared; 19.66% remained stable and 33.7% of the total cases showed a new dysplastic event after treatment. Fifteen (7.24%) out of 207 developed a squamous cell carcinoma during follow-up. Our data showed that speckled lesions are more often associated with high histological grade. The risk of malignant development does not seem to be predictable. Surrounded by the limitations of the retrospective designs, we have showed that there is no eminent benefit of surgical intervention of OED in preventing recurrences and malignant development.
Authors:
Paolo G Arduino; Antonio Surace; Mario Carbone; Alessandra Elia; Gianluca Massolini; Sergio Gandolfo; Roberto Broccoletti
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Publication Detail:
Type:  Journal Article     Date:  2009-05-18
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  38     ISSN:  1600-0714     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-10-29     Revised Date:  2010-09-03    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  540-4     Citation Subset:  D; IM    
Affiliation:
Division of Otorhinolaryngology, Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, University of Turin, Turin, Italy. paolo.arduino@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma in Situ / pathology
Carcinoma, Squamous Cell / pathology
Cell Transformation, Neoplastic / pathology
Cryosurgery
Epithelium / pathology,  surgery
Female
Follow-Up Studies
Humans
Laser Therapy
Longitudinal Studies
Male
Middle Aged
Mouth Diseases / pathology,  surgery
Mouth Mucosa / pathology*,  surgery
Mouth Neoplasms / pathology
Precancerous Conditions / pathology,  surgery
Recurrence
Remission, Spontaneous
Retrospective Studies
Risk Factors
Sex Factors
Tongue Neoplasms / pathology
Treatment Outcome
Comments/Corrections
Comment In:
J Evid Based Dent Pract. 2010 Sep;10(3):167-8   [PMID:  20797665 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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