|Outcome of oral dysplasia: a retrospective hospital-based study of 207 patients with a long follow-up.|
|PMID: 19453839 Owner: NLM Status: MEDLINE|
|The aim of this retrospective hospital-based study was to review and evaluate the long-term outcome of patients with oral epithelial dysplasia (OED), with or without surgical intervention, to identify factors affecting clinical course and malignant evolution. Patients with a follow-up of at least 12 months were included. Data collected were statistically analyzed. The mean age was 63.58 years for women (n = 100) and 64.17 years for men (n = 107). One hundred and thirty-five of the patients had lesions with histopathological features of mild OED, 50 had moderate OED and 22 had severe OED. Gender and risk factors seemed not to be related with the development of OED. One hundred and thirty-three patients underwent active treatment. During the period considered, 39.4% of the 207 lesions disappeared; 19.66% remained stable and 33.7% of the total cases showed a new dysplastic event after treatment. Fifteen (7.24%) out of 207 developed a squamous cell carcinoma during follow-up. Our data showed that speckled lesions are more often associated with high histological grade. The risk of malignant development does not seem to be predictable. Surrounded by the limitations of the retrospective designs, we have showed that there is no eminent benefit of surgical intervention of OED in preventing recurrences and malignant development.|
|Paolo G Arduino; Antonio Surace; Mario Carbone; Alessandra Elia; Gianluca Massolini; Sergio Gandolfo; Roberto Broccoletti|
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|Type: Journal Article Date: 2009-05-18|
|Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Volume: 38 ISSN: 1600-0714 ISO Abbreviation: J. Oral Pathol. Med. Publication Date: 2009 Jul|
|Created Date: 2009-07-14 Completed Date: 2009-10-29 Revised Date: 2010-09-03|
Medline Journal Info:
|Nlm Unique ID: 8911934 Medline TA: J Oral Pathol Med Country: Denmark|
|Languages: eng Pagination: 540-4 Citation Subset: D; IM|
|Division of Otorhinolaryngology, Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, University of Turin, Turin, Italy. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Carcinoma in Situ / pathology
Carcinoma, Squamous Cell / pathology
Cell Transformation, Neoplastic / pathology
Epithelium / pathology, surgery
Mouth Diseases / pathology, surgery
Mouth Mucosa / pathology*, surgery
Mouth Neoplasms / pathology
Precancerous Conditions / pathology, surgery
Tongue Neoplasms / pathology
|J Evid Based Dent Pract. 2010 Sep;10(3):167-8
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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