Document Detail

Outcome of neonates with persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide.
MedLine Citation:
PMID:  12296412     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study assessed the outcome of nitric oxide treatment in infants with persistent pulmonary hypertension of the newborn (PPHN) who failed high frequency oscillatory ventilation (HFOV). METHOD: This study was conducted from July 1, 2000 to June 30, 2001 at the neonatal intensive care unit of Queen Sirikit National Institute of Child Health. Nitric oxide was administered to 20 infants, > or = 34 weeks gestational age who were diagnosed with PPHN and had two oxygenation index > or = 20 at least 30 minutes apart after HFOV treatment. RESULTS: Nitric oxide inhalation significantly improved the oxygenation index, a/A ratio, A-a gradient (p<0.05) and directly measured partial pressure arterial oxygenation. Oxygen saturation improved within ten minutes after nitric oxide inhalation. The survival rate was 85 per cent. Meconium aspiration syndrome was the most common cause of PPHN. No acute complication was found during nitric oxide administration. CONCLUSION: Inhalation of nitric oxide increased the blood oxygen tension of infants with PPHN without using a surfactant and ECMO. The authors suggest that inhalation nitric oxide is a useful adjunctive therapy for these patients.
Uraiwan Chotigeat; Meera Khorana; Wiboon Kanjanapatakul
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  85     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-09-25     Completed Date:  2002-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  800-7     Citation Subset:  IM    
Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok, Thailand.
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MeSH Terms
Administration, Inhalation
Bronchodilator Agents / administration & dosage*,  therapeutic use*
Hypertension, Pulmonary / drug therapy*
Infant, Newborn
Nitric Oxide / administration & dosage*,  therapeutic use*
Outcome Assessment (Health Care)*
Reg. No./Substance:
0/Bronchodilator Agents; 10102-43-9/Nitric Oxide

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