Document Detail


Outcome of in-vitro fertilization treatment and DDT levels in serum and follicular fluid.
MedLine Citation:
PMID:  19865049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although p,p'-dichlorodiphenyltrichloroethane (DDT) is banned for agricultural purpose in Saudi Arabia, it is occasionally used to control vector-borne diseases in certain regions of the country. MATERIAL/METHODS: A case-control study was designed to investigate the possible effects of DDT and its metabolites on pregnancy and fertilization rate outcome. The study population was composed of 619 Saudi women (age 19-50 years) who sought in-vitro fertilization (IVF) treatment between 2002 and 2003. RESULTS: p,p'-DDE, the main metabolite of DDT, was the most frequently detected residue in serum or follicular fluid, with mean values of 1.646 microg/L and 0.407 microg/L, respectively. After controlling for many potential confounding variables, multiple logistic regression analysis revealed no association between pregnancy outcome or fertilization rate and p,p'-DDE levels in serum or follicular fluid. CONCLUSIONS: The inability to identify an effect may be related to the comparatively low concentrations of DDE in our population. But because p,p'-DDE was detected in the serum of 77.7% our participants, it should be considered as a matter of public heath concern. Currently there is no active source of DDT in our region; therefore, further studies are needed to identify sources in order to develop preventive measures because we can not exclude its potential reproductive toxicity.
Authors:
Iman Al-Saleh; Serdar Coskun; Inaam El-Doush; Grisellhi Billedo; Abdullah Mashhour; Kamal Jaroudi; Abdulaziz Al-Shahrani; Hind Al-Mayman; Gamal Mohamed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  15     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-29     Completed Date:  2010-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  BR320-33     Citation Subset:  IM    
Affiliation:
Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. iman@kfshrc.edu.sa
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
DDT / blood*
Demography
Dichlorodiphenyl Dichloroethylene / blood
Dichlorodiphenyldichloroethane / blood
Female
Fertilization in Vitro*
Follicular Fluid / chemistry*
Humans
Middle Aged
Pregnancy
Pregnancy Outcome*
Regression Analysis
Reproduction
Risk Factors
Saudi Arabia
Young Adult
Chemical
Reg. No./Substance:
50-29-3/DDT; 72-54-8/Dichlorodiphenyldichloroethane; 72-55-9/Dichlorodiphenyl Dichloroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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