Document Detail

Outcome in schizoaffective, psychotic, and nonpsychotic depression. Course during a six- to 24-month follow-up.
MedLine Citation:
PMID:  6742979     Owner:  NLM     Status:  MEDLINE    
In the National Institute of Mental Health Collaborative Study of the Psychobiology of Depression, six-month follow-up evaluations are available for 24 patients with schizoaffective disorder (depressed type), 56 with psychotic depression, and 274 with nonpsychotic major depression. Outcome for patients with schizoaffective depression was significantly worse than for patients with nonpsychotic depression. The psychotic depression group held an intermediate position on most outcome measures and on psychosocial measures had outcomes significantly worse than those of the nonpsychotic group. Recovery rates assumed a very similar pattern in another cohort admitted more than 40 years ago and followed up without somatic treatment. Follow-ups of 12, 18, and 24 months are available for proportions of each diagnostic group. Survival curves suggest similar outcomes in psychotic depression and nonpsychotic depression, whereas outcomes in schizoaffective depression remain disparate. These trends together with family history studies suggest that a small proportion of patients with schizoaffective disorder, depressed type, will have a long-term course consistent with schizophrenia. Moreover, these data show that outcome studies of schizoaffective disorder must control for follow-up length and the effects of psychosis per se.
W Coryell; P Lavori; J Endicott; M Keller; M VanEerdewegh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  41     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-08-21     Completed Date:  1984-08-21     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  787-91     Citation Subset:  AIM; IM    
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MeSH Terms
Bipolar Disorder / diagnosis,  psychology,  therapy
Depressive Disorder / diagnosis*,  psychology,  therapy
Follow-Up Studies
Outcome and Process Assessment (Health Care)*
Psychiatric Status Rating Scales
Psychotic Disorders / diagnosis*,  psychology,  therapy
Schizophrenic Psychology
Grant Support
2 U01 MH25478-09/MH/NIMH NIH HHS; R01 MH025478/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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