Document Detail

Outcome in obstetric care related to oxytocin use. A population-based study.
MedLine Citation:
PMID:  16929414     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to investigate the delivery outcome in relation to oxytocin use in labor. METHODS: We studied 106,755 deliveries from 1995 to 2002 in the Perinatal Revision South, a population-based register comprising information from 10 hospitals in southern Sweden. RESULTS: Oxytocin use in labor increased from 27.6% in 1995/96 to 33.2% in 2001/02 (p<0.000006). Oxytocin was administered to 47.7% of the nulliparas and 18.5% of the multiparas. There were large differences between hospitals (range among nulliparas: 32.6-60.4%; among multiparas: 13.9-27.0%). After exclusion of deliveries with induction of labor and deliveries lasting >12 h, there was a significant association between oxytocin use and Apgar score < 7 at 5 min (OR 2.3; 95% CI 1.8-2.9), need for neonatal intensive care (OR 1.6; 95% CI 1.5-1.7), and operative delivery (OR 4.0; 95% CI 3.7-4.2). CONCLUSIONS: In deliveries with relatively short duration (< or =12 h), a significant association was seen between oxytocin use and adverse outcome. Even though the results are difficult to interpret, the significant difference between the use of oxytocin in different hospitals, as well as the increase of oxytocin use over time, calls for a randomized controlled study to elucidate the advantages and disadvantages of oxytocin use during labor and delivery.
Maria E Oscarsson; Isis Amer-Wåhlin; Hakan Rydhstroem; Karin Källén
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  85     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-24     Completed Date:  2006-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1094-8     Citation Subset:  IM    
Centre for Reproductive Epidemiology (Tornblad's Institute), Lund University, Lund, Sweden.
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MeSH Terms
Acidosis / epidemiology
Apgar Score
Cesarean Section / statistics & numerical data
Confidence Intervals
Delivery, Obstetric / statistics & numerical data
Gestational Age
Infant, Newborn
Intensive Care, Neonatal / statistics & numerical data
Labor, Induced / methods*,  statistics & numerical data
Labor, Obstetric / drug effects*
Maternal Age
Odds Ratio
Oxytocics / adverse effects,  therapeutic use*
Oxytocin / adverse effects,  therapeutic use*
Pregnancy Outcome*
Time Factors
Reg. No./Substance:
0/Oxytocics; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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