| Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy. | |
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MedLine Citation:
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PMID: 16924029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperglycemia independently predicts poor outcome after acute ischemic stroke. CLOTBUST (Combined Lysis Of Thrombus in Brain ischemia using transcranial Ultrasound and Systemic tPA) demonstrated that ultrasound-augmented thrombolysis improves recanalization and 24-hour outcome in patients with acute ischemic stroke. We hypothesized that ultrasound would preferentially benefit hyperglycemic patients, and reviewed CLOTBUST with respect to admission glucose and good outcome. We found that ultrasound's benefit on 90-day outcome was primarily apparent at higher glucose levels, suggesting that ultrasound therapy may improve outcome following hyperglycemic stroke. |
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Authors:
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S R Martini; M D Hill; A V Alexandrov; C A Molina; T A Kent |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 67 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-22 Completed Date: 2006-09-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 700-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Baylor College of Medicine and the Michael E. DeBakey Veterans Affairs Medical Center Stroke Program, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Glucose / analysis Combined Modality Therapy / statistics & numerical data Comorbidity Female Humans Hyperglycemia / blood, epidemiology*, therapy* Male Middle Aged Outcome Assessment (Health Care) Retrospective Studies Risk Assessment / methods Risk Factors Stroke / blood, epidemiology*, therapy* Thrombolytic Therapy / statistics & numerical data* Ultrasonic Therapy / statistics & numerical data* United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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1K23NS02229-01/NS/NINDS NIH HHS; 1P50NS044227/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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