| Outcome in breast molecular subtypes according to nodal status and surgical procedures. | |
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MedLine Citation:
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PMID: 23312273 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of our study was to evaluate the surgical treatment and outcome of breast cancer according to molecular subtypes. METHODS: We identified 1,194 patients consecutively treated for primary breast cancer from 2004 to 2010. The type of surgery, pathological findings, local recurrence, and distant metastasis were evaluated for 5 molecular subtypes: luminal A and B, luminal HER2 (Human Epidermal Growth Factor Receptor 2), HER2 , and triple negative. RESULTS: Breast-conserving surgery (BCS) was performed more frequently in luminal A (70.6%), triple-negative (66.2%), and luminal HER2 tumors (60.9%) (P < .001). A sentinel node biopsy was performed more frequently in luminal A (60%), and luminal HER2 (29.3%) types (P < .001). Among the 791 BCS, positive nodes were observed more often in HER2 (50%) and luminal B (44.9%) types (P = .0003). The number of local recurrences was higher in the node-negative luminal B subtype (3.4%). CONCLUSIONS: Molecular subtypes exert an impact on BCS and nodal surgery rates. The local relapse rates are influenced by the molecular subtypes according to the nodal status. |
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Authors:
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Chafika Mazouni; Françoise Rimareix; Marie-Christine Mathieu; Catherine Uzan; Céline Bourgier; Fabrice André; Suzette Delaloge; Jean-Rémi Garbay |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-9 |
Journal Detail:
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Title: American journal of surgery Volume: - ISSN: 1879-1883 ISO Abbreviation: Am. J. Surg. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Breast Surgery, Institut Gustave Roussy, Villejuif, France. Electronic address: chafika.mazouni@igr.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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