| Outcome in stable patients with acute pulmonary embolism who had right ventricular enlargement and/or elevated levels of troponin I. | |
| | |
MedLine Citation:
|
PMID: 20691316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Normotensive patients with acute pulmonary embolism (PE) who have increased troponin levels and right ventricular (RV) dysfunction are thought to be at high risk of death, but the level of risk is unclear. We retrospectively evaluated outcome in 1,273 stable patients with PE who had echocardiographic evaluations of RV size and/or measurement of cardiac troponin I (cTnI). In-hospital all-cause mortality was higher in those with RV enlargement (8.0%, 19 of 237, vs 3.3%, 22 of 663, p = 0.003). With an increased cTnI, irrespective of RV enlargement, all-cause mortality was 8.0% (28 of 330) versus 1.9% (15 of 835) in patients with a normal cTnI (p <0.0001). In patients with an increased cTnI combined with an enlarged right ventricle, all-cause mortality was 10.2% (12 of 118) compared to 1.9% (8 of 421) in patients who had neither (p <0.0001). These data show that increased levels of cTnI and RV enlargement are associated with an adverse outcome in stable patients with acute PE. In conclusion, increased levels of cTnI in combination with RV enlargement might indicate a group who would benefit from intense monitoring and aggressive treatment if subsequently indicated. The outcomes, however, were not extreme enough to warrant routine thrombolytic therapy. |
| | |
Authors:
|
Paul D Stein; Fadi Matta; Muhammad Janjua; Abdo Y Yaekoub; Fadel Jaweesh; Ahmed Alrifai |
Related Documents
:
|
8492056 - Correlates of myoelectric asymmetry detected in low back pain patients using hand-held ... 20122556 - Heart failure with preserved versus reduced left ventricular systolic function: a prosp... 18983646 - Feasibility and initial experience of assessment of mechanical dyssynchrony using cardi... 3665006 - Results of surgery for hypertrophic obstructive cardiomyopathy. 2188296 - Extracorporeal shock wave lithotripsy of calcified gallstones. work in progress. 17630916 - Use of radiopharmaceuticals for diagnosis, treatment, and follow-up of differentiated t... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of cardiology Volume: 106 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-09 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 558-63 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine and Research and Advanced Studies Program, Michigan State University, East Lansing, MI, USA. steinp@trinity-health.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Biological Markers / blood Female Hospital Mortality Humans Hypertrophy, Right Ventricular / blood, mortality, physiopathology*, ultrasonography Male Middle Aged Pulmonary Embolism / blood, mortality*, physiopathology* Retrospective Studies Risk Assessment Treatment Outcome Troponin I / blood* Ventricular Dysfunction, Right / blood, mortality, physiopathology* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Troponin I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Meta-Analysis of Pulmonary Valve Replacement After Operative Repair of Tetralogy of Fallot.
Next Document: Relation of serum phosphorus levels to ankle brachial pressure index (from the Third National Health...