Document Detail


Outcome in 53 patients with spinal cord cavernomas.
MedLine Citation:
PMID:  18207494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Prevalence of cerebral cavernomas in the general population is close to 0.5%. In contrast, SCCs are rare. The aim of this study was to determine the outcome of SCC in a large sample of patients. METHODS: Clinical and neuroradiologic findings were retrospectively collected in a multicentric study. Diagnosis was based on pathologic criteria or MR findings. RESULTS: Fifty-three patients were included (26 males, 27 females). Mean age at onset of symptoms was 40.2 years (11-80 years). Initial symptoms were progressive (32) or acute myelopathy (20). One case was asymptomatic. Triggering factors were found in 14 of the patients (26%). Clinical symptoms were related to spinal cord compression (27) and hemorrhage (22). Spinal cord cavernoma was thoracic in 41 cases and cervical in 12. Mean size of the lesions was 16.3 mm (3-54 mm). In the 40 surgical patients, long-term follow-up was available in 37 cases for a mean time of 7.3 years (0.4-50 years). During the follow-up period, 20 patients improved, 6 remained on their preoperative baseline, and 11 got worse. Surgical improvement was more often found in posterior rather than anterior location. Using McCormick classification, 22 patients were autonomous (grades 1-2), 12 handicapped (grade 3), and 3 bedridden (grade 4) at the end of the follow-up. CONCLUSIONS: This study has defined clinical and MR patterns of spinal cavernomas. Surgery lastingly improved more than half of the patients.
Authors:
Pierre Labauge; Stéphane Bouly; Fabrice Parker; Sophie Gallas; Evelyne Emery; Hugues Loiseau; Jean Paul Lejeune; Michel Lonjon; François Proust; Sergio Boetto; Sophie Coulbois; Jean Auque; Jacques Boulliat;
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2008-01-22
Journal Detail:
Title:  Surgical neurology     Volume:  70     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-81; discussion 181     Citation Subset:  IM    
Affiliation:
Service de Neurologie, CHU de Nîmes, 30029 France. labauge@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
Child
Decompression, Surgical
Early Diagnosis
Female
Hemangioma, Cavernous, Central Nervous System / pathology*,  radiography,  surgery*
Hemorrhage / etiology,  pathology,  surgery
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neurosurgical Procedures
Prognosis
Retrospective Studies
Spinal Canal / anatomy & histology,  radiography,  surgery
Spinal Cord / pathology*,  radiography,  surgery*
Spinal Cord Compression / etiology,  pathology,  surgery
Spinal Cord Neoplasms / pathology*,  radiography,  surgery*
Treatment Outcome
Investigator
Investigator/Affiliation:
Pierre Labauge / ; Stephane Bouly / ; Pablo Bouillot / ; Fabrice Parker / ; Sophie Gallas / ; Evelyne Emery / ; Hugues Loiseau / ; Jean Paul Lejeune / ; Michel Lonjon / ; Philippe Paquis / ; Francois Proust / ; Sergio Boetto / ; Sophie Coulbois / ; Jean Auque / ; Jacques Bouillat /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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