Document Detail


Outcome implications of the International Maternal Phenylketonuria Collaborative Study (MPKUCS): 1994.
MedLine Citation:
PMID:  8828636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well established that women with phenylketonuria who remain untreated during pregnancy face serious problems in offspring outcome. Surveys have documented that maternal phenylalanine (Phe) blood concentrations above 1200 mumol/l are associated with microcephaly, congenital heart disease and intrauterine growth retardation among their offspring. To investigate the efficacy of the Phe restricted diet, the National Institute of Child Health and Human Development in Bethesda Maryland developed an international study to evaluate fetal outcome in pregnancies treated with the Phe restricted diet. The study involves over 100 metabolic clinics in the United States, Canada and Germany, and is now in its 10th year. The results included in this report are still preliminary in nature and the actual risk for such pregnancies remains to be determined.
Authors:
R Koch; H Levy; W Hanley; R Matalon; B Rouse; F Trefz; F de la Cruz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pediatrics     Volume:  155 Suppl 1     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-01-13     Completed Date:  1997-01-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  S162-4     Citation Subset:  IM    
Affiliation:
Childrens Hospital Los Angeles, Division of Medical Genetics, CA 90027, USA.
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MeSH Terms
Descriptor/Qualifier:
Diet, Protein-Restricted*
Female
Humans
Multicenter Studies as Topic
Phenylketonuria, Maternal / diet therapy*
Pregnancy
Pregnancy Outcome*
Grant Support
ID/Acronym/Agency:
N01-HD-2-3148/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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