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Outcome of high-risk acute myeloid leukemia after allogeneic hematopoietic cell transplantation: negative impact of abnl(17p) and -5/5q-
MedLine Citation:
PMID:  22855604     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The European LeukemiaNet classification combines a heterogeneous group of aberrations as high risk (HR) abnormalities. Our goal was to investigate the outcomes associated with distinct high-risk chromosomal abnormalities in acute myeloid leukemia (AML) after allogeneic hematopoietic stem-cell transplantation (HSCT). We performed a retrospective cohort analysis in patients with HR AML who received first, HLA-compatible allogeneic HSCT between 01/2005 and 12/2008. Data from 236 patients with a median age of 55 years were included. Since CK, -5/5q-, and abnl(17p) are overlapping categories, a hierarchical classification system based on the presence or absence of abnl(17p) and -5/5q- was developed. Patients with abnl(17p) had a 2-year EFS of 11% (95% CI, 0% to 25%), patients with -5/5q- but no abnl(17p) a 2-year EFS of 29% (95% CI, 14% to 44%), and patients with HR AML but neither of the two marker lesions a 2-year EFS of 49% (95% CI, 39% to 59%). Notably, complex and monosomal karyotypes lost their prognostic value when these marker lesions were excluded. In conclusion, hierarchical classification of HR karyotypes by two marker lesions, abnl(17p) and -5/5q-, is effective in prognostication of the outcome of allogeneic HSCT in AML.
Authors:
Jan M Middeke; Dietrich Beelen; Michael Stadler; Gudrun Göhring; Brigitte Schlegelberger; Herrad Baurmann; Gesine Bug; Frauke Bellos; Brigitte Mohr; Stefanie Buchholz; Rainer Schwerdtfeger; Hans Martin; Ute Hegenbart; Gerhard Ehninger; Martin Bornhäuser; Johannes Schetelig
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-31
Journal Detail:
Title:  Blood     Volume:  -     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Universitaetsklinikum Carl Gustav Carus der TU Dresden, Medizinische Klinik und Poliklinik I, Dresden, Germany;
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