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OUTCOME OF GRAFT-FAILURE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: STUDY OF 89 PATIENTS.
MedLine Citation:
PMID:  24913510     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT Strategies for reversing graft-failure (GF) after allogeneic stem cell transplant (SCT) depend on the options available in each situation. GF was reported in 16 Spanish institutions from January 2006 to July 2011. Primary GF was defined as ANC >0.5x10(9)/L not reached by day +28 after SCT from peripheral blood (PB) or bone marrow (BM) progenitors and by day +42 after SCT from unrelated cord blood (UCB) progenitors. Secondary GF was defined as a recurrent ANC<0.5x10(9)/L. Eighty-nine patients with GF were reported, and 80 patients received a second SCT. The 5-yr. survival probability was 31% (95%CI: 18%-44%), and the incidences of non-relapse mortality and relapse estimated by competing risks were 47% [95%CI: 36%-58%] and 21% [95%CI: 4%-28%]. The strategy adopted to treat GF was heterogeneous and no approach could be unequivocally recommended for this situation. The prognosis of patients with GF was poor even after successful recovery from GF.
Authors:
Christelle Ferrà; Jaime Sanz; Miguel-Angel Díaz-Pérez; Mireia Morgades; Jorge Gayoso; José-Rafael Cabrera; Teresa Villaescusa; María-Antonia Sampol; Francesc Fernández-Avilés; Carlos Solano; Miguel Ortín; Rafael Duarte; Marian Cuesta; Inmaculada Heras; Javier de la Serna; José-María Moraleda; Cristina Barrenetxea; Marta González-Vicent; Guillermo Sanz; Josep-Maria Ribera;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-24     Citation Subset:  -    
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