Document Detail

Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital.
MedLine Citation:
PMID:  20636988     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation.
CASE OR SERIES SUMMARY: Three dogs without preceding seizure activity, were diagnosed with a single extrahepatic PSS. Following standard preoperative medical therapy, an ameroid constrictor was placed surgically. Recovery was uneventful until spontaneous SE developed 46-96 hours after surgery. After unsuccessful seizure control with benzodiazepines, dogs were treated with a bolus of propofol followed by a propofol constant rate infusion. Phenobarbital was concurrently administered and supportive care was optimized. All dogs recovered uneventfully over the next 7-9 days. Over the following months phenobarbital was slowly tapered. All dogs have been free from antiepileptic drugs for several months, without recurrence of neurologic signs.
NEW OR UNIQUE INFORMATION PROVIDED: In this case series, we describe the treatment of 3 dogs with propofol and phenobarbital for refractory SE following attenuation of a single congenital PSS. After weaning of the propofol constant rate infusion, and tapering and discontinuation of phenobarbital over the following months, all dogs experienced a complete recovery. This study provides evidence that use of propofol in combination with phenobarbital may be efficacious for management of SE in dogs after PSS surgery.
Kris Gommeren; Stéphanie Claeys; Hilde de Rooster; Annick Hamaide; Sylvie Daminet
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)     Volume:  20     ISSN:  1476-4431     ISO Abbreviation:  J Vet Emerg Crit Care (San Antonio)     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-11-15     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101152804     Medline TA:  J Vet Emerg Crit Care (San Antonio)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  346-51     Citation Subset:  IM    
Department of Clinical Sciences, School of Veterinary Medicine, University of Liège, 4000 Liège, Belgium.
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MeSH Terms
Anticonvulsants / therapeutic use*
Dog Diseases / congenital,  etiology*,  surgery
Liver Diseases / veterinary*
Phenobarbital / therapeutic use*
Portal System / abnormalities*,  surgery
Postoperative Complications / drug therapy,  veterinary*
Propofol / therapeutic use*
Retrospective Studies
Status Epilepticus / drug therapy,  veterinary*
Reg. No./Substance:
0/Anticonvulsants; 2078-54-8/Propofol; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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