| Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital. | |
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MedLine Citation:
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PMID: 20636988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation. CASE OR SERIES SUMMARY: Three dogs without preceding seizure activity, were diagnosed with a single extrahepatic PSS. Following standard preoperative medical therapy, an ameroid constrictor was placed surgically. Recovery was uneventful until spontaneous SE developed 46-96 hours after surgery. After unsuccessful seizure control with benzodiazepines, dogs were treated with a bolus of propofol followed by a propofol constant rate infusion. Phenobarbital was concurrently administered and supportive care was optimized. All dogs recovered uneventfully over the next 7-9 days. Over the following months phenobarbital was slowly tapered. All dogs have been free from antiepileptic drugs for several months, without recurrence of neurologic signs. NEW OR UNIQUE INFORMATION PROVIDED: In this case series, we describe the treatment of 3 dogs with propofol and phenobarbital for refractory SE following attenuation of a single congenital PSS. After weaning of the propofol constant rate infusion, and tapering and discontinuation of phenobarbital over the following months, all dogs experienced a complete recovery. This study provides evidence that use of propofol in combination with phenobarbital may be efficacious for management of SE in dogs after PSS surgery. |
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Authors:
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Kris Gommeren; Stéphanie Claeys; Hilde de Rooster; Annick Hamaide; Sylvie Daminet |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) Volume: 20 ISSN: 1476-4431 ISO Abbreviation: J Vet Emerg Crit Care (San Antonio) Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-11-15 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101152804 Medline TA: J Vet Emerg Crit Care (San Antonio) Country: United States |
Other Details:
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Languages: eng Pagination: 346-51 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, School of Veterinary Medicine, University of Liège, 4000 Liège, Belgium. kris.gommeren@ulg.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / therapeutic use* Dog Diseases / congenital, etiology*, surgery Dogs Female Liver Diseases / veterinary* Male Phenobarbital / therapeutic use* Portal System / abnormalities*, surgery Postoperative Complications / drug therapy, veterinary* Propofol / therapeutic use* Retrospective Studies Status Epilepticus / drug therapy, veterinary* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 2078-54-8/Propofol; 50-06-6/Phenobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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