| Outcome of four high-risk pregnancies in female liver transplant recipients on tacrolimus immunosuppression. | |
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MedLine Citation:
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PMID: 16504718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancies in women after liver transplantation are considered high risk due to the greater rate of complications observed in immunosuppressed graft recipients. We report successful outcomes of four high-risk pregnancies in female liver transplant recipients on tacrolimus-based immunosuppression. The patients, aged 23 to 32 years, at the time of conception were 12 to 59 months from transplantation (mean 30 months). Preterm labor was the most important pregnancy complication observed in these patients. One episode of acute graft rejection was observed. A variable demand for tacrolimus was noted during pregnancy. Despite complications all four pregnancies were successful. The mean gestational age at delivery was 34.4 weeks. The birth weight of the newborns varied from 1410 to 3490 g (mean 2303 g) and the mean Apgar score was 8. No structural malformations or early complications were observed in the newborns. Excluding the patient with acute rejection, the remaining three cases showed all liver parameters to remain stable. |
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Authors:
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Z Jabiry-Zieniewicz; P Kamiński; B Pietrzak; A Cyganek; K Bobrowska; J Ziółkowski; U Ołdakowska-Jedynak; K Zieniewicz; L Paczek; I Jankowska; M Wielgoś; M Krawczyk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 38 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2006 Jan-Feb |
Date Detail:
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Created Date: 2006-02-28 Completed Date: 2006-05-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 255-7 Citation Subset: IM |
Affiliation:
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First Department of Obstetrics and Gynecology, Warsaw Medical University, Pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight Female Humans Immunosuppressive Agents / therapeutic use Infant, Newborn Liver Function Tests Liver Transplantation / adverse effects*, immunology* Obstetric Labor, Premature / epidemiology Pregnancy Pregnancy Complications / physiopathology* Pregnancy Outcome Tacrolimus / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 109581-93-3/Tacrolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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