Document Detail

Outcome of fetuses with enlarged nuchal translucency and normal karyotype.
MedLine Citation:
PMID:  9674085     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to examine the relationship between nuchal translucency measurements and outcome of pregnancy with special regard to fetuses with an enlarged nuchal translucency and a normal karyotype. Fetal nuchal translucency measurements were performed on consecutive mothers attending the prenatal diagnosis center of our hospital. A complete follow-up was obtained in 88.4% of the cases. Of the 74 fetuses (4.4%) with an enlarged nuchal translucency (> or = 3 mm), 25 (33.8%) had an abnormal karyotype. Two pregnancies ended in a spontaneous abortion before karyotyping was performed. In the remaining 47 eukaryotic fetuses with enlarged nuchal translucency, five (10.6%) had a structural anomaly, two were affected by genetic syndromes (4.2%) and an additional four fetuses (8.5%) were affected by a single-gene disorder. A spontaneous abortion or an intrauterine death occurred in 6.4% and in 2.1% of these fetuses, respectively. The total incidence of an unfavorable outcome in the group of chromosomally normal fetuses with enlarged nuchal translucency was 32%. In contrast, in the group with a normal nuchal translucency (< 3 mm), the incidence of an unfavorable outcome was 7.5%. There is a strong association between enlarged nuchal translucency measurements and congenital (structural and genetic) abnormalities, as assessed by receiver operator characteristic analysis. This may represent, in fetuses with a normal karyotype, a non-specific sign of a disturbance in the developmental process. In these cases, detailed ultrasound surveillance is recommended.
C M Bilardo; E Pajkrt; I de Graaf; B W Mol; O P Bleker
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  11     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-06     Completed Date:  1998-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Chromosomes / physiology*
Congenital Abnormalities / diagnosis*,  epidemiology
Fetal Death
Fetal Viability
Follow-Up Studies
Gestational Age
Middle Aged
Neck / abnormalities,  embryology,  ultrasonography*
Pregnancy Outcome*
Prospective Studies
ROC Curve
Ultrasonography, Prenatal*
Comment In:
Ultrasound Obstet Gynecol. 1998 Jun;11(6):388-90   [PMID:  9674083 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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