| Outcome of fetuses with enlarged nuchal translucency and normal karyotype. | |
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MedLine Citation:
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PMID: 9674085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to examine the relationship between nuchal translucency measurements and outcome of pregnancy with special regard to fetuses with an enlarged nuchal translucency and a normal karyotype. Fetal nuchal translucency measurements were performed on consecutive mothers attending the prenatal diagnosis center of our hospital. A complete follow-up was obtained in 88.4% of the cases. Of the 74 fetuses (4.4%) with an enlarged nuchal translucency (> or = 3 mm), 25 (33.8%) had an abnormal karyotype. Two pregnancies ended in a spontaneous abortion before karyotyping was performed. In the remaining 47 eukaryotic fetuses with enlarged nuchal translucency, five (10.6%) had a structural anomaly, two were affected by genetic syndromes (4.2%) and an additional four fetuses (8.5%) were affected by a single-gene disorder. A spontaneous abortion or an intrauterine death occurred in 6.4% and in 2.1% of these fetuses, respectively. The total incidence of an unfavorable outcome in the group of chromosomally normal fetuses with enlarged nuchal translucency was 32%. In contrast, in the group with a normal nuchal translucency (< 3 mm), the incidence of an unfavorable outcome was 7.5%. There is a strong association between enlarged nuchal translucency measurements and congenital (structural and genetic) abnormalities, as assessed by receiver operator characteristic analysis. This may represent, in fetuses with a normal karyotype, a non-specific sign of a disturbance in the developmental process. In these cases, detailed ultrasound surveillance is recommended. |
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Authors:
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C M Bilardo; E Pajkrt; I de Graaf; B W Mol; O P Bleker |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 11 ISSN: 0960-7692 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-10-06 Completed Date: 1998-10-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 401-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromosomes / physiology* Congenital Abnormalities / diagnosis*, epidemiology Female Fetal Death Fetal Viability Follow-Up Studies Gestational Age Humans Incidence Karyotyping Middle Aged Neck / abnormalities, embryology, ultrasonography* Pregnancy Pregnancy Outcome* Prospective Studies ROC Curve Ultrasonography, Prenatal* |
| Comments/Corrections | |
Comment In:
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Ultrasound Obstet Gynecol. 1998 Jun;11(6):388-90
[PMID:
9674083
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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