| Outcome of fetal cystic hygroma and experience of intrauterine treatment. | |
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MedLine Citation:
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PMID: 11173958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review our cases of fetal cystic hygroma and to examine the prognostic factors with the goal of establishing criteria for the intrauterine treatment for cystic hygroma. PATIENTS AND METHODS: Thirty-one cases of fetal cystic hygroma were managed by us from January 1988 to December 1997, and 21 cases were available for analysis. Three prognostic factors, namely chromosomal abnormality, structural anomaly and hydrops fetalis, were evaluated. We treated 2 cases of cystic hygroma associated with hydrops fetalis in utero using OK-432 injection under ultrasound guidance. RESULTS: The fetuses without any of the prognostic factors listed above showed a good prognosis throughout the fetal and neonatal periods. However, in this group, 2 infants with large tumors died of hemorrhage from the tumor at 6 months and 3 years of age, respectively. Cases with hydrops fetalis without chromosomal abnormalities or structural anomalies (5 cases) resulted in either intrauterine fetal death (IUFD, 2 cases) or early perinatal neonatal death (early PND, 3 cases). The cause of early PND was circulatory failure. Most of the hydrops cases with either a chromosomal abnormality or structural anomaly resulted in IUFD before 22 weeks of gestation. The size of the cyst decreased in 1 of 2 cases treated in utero. CONCLUSIONS: The fetal cases of cystic hygroma showing hydrops fetalis without chromosomal abnormalities or structural anomalies are considered to be possible candidates for intrauterine therapy. Those with very large cystic hygroma without any of the three prognostic factors are also thought to be candidates for fetal treatment. Based on our clinical experience, sclerotherapy using OK-432 is considered to be a treatment option in selected cases with fetal cystic hygroma. |
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Authors:
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K Ogita; S Suita; T Taguchi; T Yamanouchi; K Masumoto; K Tsukimori; H Nakano |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 16 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2001 Mar-Apr |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-04-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 105-10 Citation Subset: IM |
Affiliation:
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Department of Pediatric Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan. Keiko813@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations Congenital Abnormalities Fatal Outcome Female Fetal Death / etiology Fetal Diseases / therapy* Humans Hydrops Fetalis / complications Infant, Newborn Lymphangioma, Cystic / complications, genetics, therapy* Pregnancy Prognosis Sclerosing Solutions / therapeutic use Sclerotherapy Treatment Outcome* Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Sclerosing Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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