Document Detail

Outcome of extremely low birth weight infants (500 to 999 grams) over a 12-year period.
MedLine Citation:
PMID:  9310517     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Advances in neonatology have contributed to improved survival for extremely low birth weight (ELBW) infants. Neurodevelopmental outcome is usually reported for a single large group of infants rather than according to smaller birth weight groups because of small numbers. Our purpose was to review the neurodevelopmental outcome of a large group of ELBW infants and examine differential outcome according to birth weight. STUDY DESIGN: A total of 446 infants born between 1979 and 1991, with a birth weight of 500 to 999 g, were followed to mean age 55 months +/- 33 standard deviation. Univariate analyses of medical risk factors of birth weight, gestational age, year of birth, growth retardation, gender, inborn/outborn status, days on oxygen, intracranial hemorrhage, and social risk in relation to outcome were conducted on the group as a whole. Neurologic/developmental outcome was also analyzed by 100-g weight groups. RESULTS: A total of 61% of all infants were completely normal, with no neurologic, neurosensory, or cognitive deficits. There was no association between outcome and birth weight. There was a strong association between intracranial hemorrhage (ICH) grade III or IV and/or cystic periventricular leukomalacia (PVL) and abnormal outcome (Somers' D = .17) and ICH III/IV and/or cystic PVL and cognitive outcome (Kendall's tau = .15). Mild to moderate cognitive delays were associated with chronic lung disease (oxygen >60 days) (Kruskal-Wallis chi2 = 17.53) or high social risk (Kruskal-Wallis chi2 = 22.17). CONCLUSION: In this study of ELBW infants, low birth weight was not associated with abnormal outcome. The risk factors of ICH III-IV/cystic PVL, chronic lung disease, and high social risk were associated with abnormal outcome.
R E Piecuch; C H Leonard; B A Cooper; S A Sehring
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  100     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-10-14     Completed Date:  1997-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  633-9     Citation Subset:  AIM; IM    
Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA.
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MeSH Terms
Analysis of Variance
Birth Weight
Cerebral Hemorrhage
Child Development*
Developmental Disabilities / epidemiology
Follow-Up Studies
Infant, Newborn
Infant, Very Low Birth Weight*
Leukomalacia, Periventricular
Oxygen Inhalation Therapy
Risk Factors
Socioeconomic Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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