Document Detail

Outcome of duodenum-preserving resection of the head of the pancreas for intraductal papillary-mucinous neoplasm.
MedLine Citation:
PMID:  15237258     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The standard surgical procedure for intraductal papillary-mucinous neoplasm of the pancreatic head is pylorus-preserving pancreatoduodenectomy. A less extensive resection may be justified because most intraductal papillary-mucinous neoplasms are benign or of low-grade malignancy. AIMS AND METHODS: The outcome of duodenum-preserving pancreatic head resection with preservation of the main bile duct was evaluated retrospectively in 13 patients with a branch-type intraductal papillary-mucinous neoplasm in the head of the pancreas and with a median (range) follow-up of 60.0 (0.3-99.5) months. RESULTS: Post-operative complications included anastomotic leakage (n=3), bile duct perforation (n=1), intra-abdominal bleeding (n=3), delayed gastric emptying (n=2) and death (n=2). All the resection margins were clear of tumour on histological examination. Ten of 11 patients maintained over 90% of their pre-operative body weight. Glucose tolerance improved in 4 of 11 evaluable patients, was unchanged in 6 and worsened in 1 patient. Biliary scintigraphy showed that bile flow was delayed compared with that before surgery (8.8 +/- 1.1 vs. 19.6 +/- 4.6 min; p = 0.03). Neither recurrence nor metastasis was observed. CONCLUSION: The results of duodenum-preserving pancreatic head resection for branch duct-type intraductal papillary-mucinous neoplasm were satisfactory and provided a good quality of life.
Satoshi Hirano; Satoshi Kondo; Yoshiyasu Ambo; Eiichi Tanaka; Toshiaki Morikawa; Shunichi Okushiba; Hiroyuki Katoh
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Publication Detail:
Type:  Journal Article     Date:  2004-06-30
Journal Detail:
Title:  Digestive surgery     Volume:  21     ISSN:  0253-4886     ISO Abbreviation:  Dig Surg     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-26     Completed Date:  2004-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501808     Medline TA:  Dig Surg     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  242-5     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Department of Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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MeSH Terms
Adenocarcinoma, Mucinous / surgery*
Adenocarcinoma, Papillary / surgery*
Carcinoma, Pancreatic Ductal / surgery*
Digestive System Surgical Procedures / methods
Follow-Up Studies
Middle Aged
Pancreatic Neoplasms / surgery*
Postoperative Complications / epidemiology
Quality of Life
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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