Document Detail


Outcome of directly observed therapy short course (DOTS) regimen in a rural community of the Nigerian Niger Delta.
MedLine Citation:
PMID:  18390136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: [corrected] The objective of this retrospective study was to evaluate the outcome of directly observed therapy short course (DOTS) application in a Nigerian rural community. METHODS: A retrospective study of all the records of DOTS at the centre from January 2001 to December 2005 was compiled and features such as: age, gender, drugs used, and outcome of treatment (defaulted, cured, died, or developed multidrug resistant-TB) were considered. Also the different personnel and infrastructure at the centre for the programme were also assessed. Results were analysed using Epi Info 6 statistical software, and P values < 0.05 were considered significant. RESULTS: Two hundred and seventy four (274) cases of pulmonary TB were registered at the centre during the study period, consisting of 100 (36.5%) females and 174 (63.5%) males with a statistically significant gender difference (P<0.001). The age range with the highest number of pulmonary tuberculosis cases was 31-40 years (24.8%; n=68), and the age range with the lowest number was 71 years and above (1.1%; n=3). Treatment outcome showed that 84.7% (n=232) completed treatment with cure; 2.5% (n=7) developed multidrug resistance at completion of treatment; 5.5% (n=15) defaulted; 3.3% (n=9) died in the course of treatment, and treatment in 11 people was still ongoing. CONCLUSION: The outcome of DOTS in the present study was impressive, and the programme should be extended to other rural communities; however, more efforts should be made towards the tracing of defaulters.
Authors:
G T A Jombo; E J Peters; A N Gyuse; J P Nwankon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria     Volume:  17     ISSN:  1115-2613     ISO Abbreviation:  Niger J Med     Publication Date:    2008 Jan-Mar
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-04-30     Revised Date:  2008-07-16    
Medline Journal Info:
Nlm Unique ID:  100888321     Medline TA:  Niger J Med     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology & Parasitology, College of Medical Sciences, University of Calabar, Calabar, Nigeria. jombogodwin@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antitubercular Agents / therapeutic use*
Child
Child, Preschool
Directly Observed Therapy*
Ethambutol / therapeutic use
Female
Humans
Infant
Infant, Newborn
Isoniazid / therapeutic use
Male
Middle Aged
Mycobacterium tuberculosis
Nigeria
Patient Compliance
Pyrazinamide / therapeutic use
Retrospective Studies
Rifampin / therapeutic use
Rural Population*
Treatment Outcome*
Tuberculosis, Multidrug-Resistant
Tuberculosis, Pulmonary / drug therapy*
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 13292-46-1/Rifampin; 54-85-3/Isoniazid; 74-55-5/Ethambutol; 98-96-4/Pyrazinamide

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