Document Detail

Outcome of delivery and cause-specific mortality and severe morbidity in early infancy: a Kenyan District Hospital birth cohort.
MedLine Citation:
PMID:  13677381     Owner:  NLM     Status:  MEDLINE    
It has proven very difficult to determine the causes of early infant mortality and morbidity in Africa. We undertook a two-year, prospective birth cohort study in a rural Kenyan District Hospital to estimate cause-specific mortality and severe morbidity in infants too young to gain benefit from routine immunization approaches. A total of 2,359 infants eligible for the cohort were delivered. Of these, 136 (6%) were stillborn and 77 (3.5%) subsequently died. Prematurity (34%), birth asphyxia (27%), and infection (18.5%) were the predominant causes of death in the first 98 days of life, although infection accounted for 36% of all life-threatening illness episodes in the same period. The data suggest that health system constraints are likely to impede programmatic efforts to reduce early infant mortality and morbidity, and that infection prevention measures offer some promise for mortality reduction. Assessing the cost effectiveness of the latter, particularly for very specific interventions such as further maternal vaccination, will require very large trials.
Mike English; Ann Muhoro; Maurice Aluda; Sam Were; Amanda Ross; Norbert Peshu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  69     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-17     Completed Date:  2003-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-32     Citation Subset:  AIM; IM    
Centre for Geographic Medicine Research-Coast, Kenya Medical Research Institute, Kilifi, Kenya.
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MeSH Terms
Cause of Death
Cohort Studies
Fetal Death
Hospitals, District
Infant Mortality*
Infant, Newborn
Kenya / epidemiology
Medically Underserved Area
Pregnancy Outcome*
Prenatal Care
Prospective Studies
Rural Health Services

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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