Document Detail

Outcome of conventional IVF and ICSI on sibling oocytes in the case of isolated teratozoospermia.
MedLine Citation:
PMID:  22733316     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To reevaluate the effect of isolated teratozoospermia on IVF and determine if there was any therapeutic benefit to isolated teratozoospermia by ICSI, since there are no widely accepted criteria for the treatment technique about isolated teratozoospermia.
METHODS: A total of 441 couples with >20 million and progressive motility >30 % sperm undergoing their first IVF/ICSI cycle were included in the study between 2008 and 2010, for whom at least 8 oocytes were retrived. Isolated teratozoospermia was diagnosed in 183 of the included couples, and the rest couples (normal sperm morphology) were studied as control. Sibling oocytes were randomized to be inseminated either by ICSI or IVF. Fertilization rate, embryo quality, pregnancy rate, implantation rate and spontaneous abortion rate were assessed.
RESULTS: There was no difference in the percentage of eggs fertilized, implantation rate, pregnancy rate and spontaneous abortion rate between conventional IVF and ICSI regardless of the percentage of normal morphology. The day 3 embryonic morphology and rate of development were not different despite the insemination method and percentage of normal morphology.
CONCLUSION: Because isolated teratozoospermia did not influence the major indices of IVF and the unnecessary use of ICSI is time-consuming, costly and potential risks, couples with isolated teratozoospermia need not be subjected to ICSI.
Wei Fan; Shang Wei Li; Lei Li; Zhongying Huang; Qianhong Ma; Yan Wang; Zhun Xiao
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2012-06-26
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2013-03-11     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  905-10     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Center of Reproductive Medicine, The West China Second University Hospital, Sichuan University, Sichuan, People's Republic of China.
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MeSH Terms
Abortion, Spontaneous / pathology
Case-Control Studies
Cell Shape
Embryo Implantation
Embryo, Mammalian / cytology
Embryonic Development
Fertilization in Vitro / methods*
Infertility, Male
Oocyte Retrieval
Oocytes / cytology*,  growth & development
Pregnancy Outcome
Pregnancy Rate
Reproducibility of Results
Retrospective Studies
Sperm Count
Sperm Injections, Intracytoplasmic / methods*
Sperm Motility
Spermatozoa / cytology*
Time Factors
Treatment Outcome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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