Document Detail


Outcome of conventional IVF and ICSI on sibling oocytes in mild male factor infertility.
MedLine Citation:
PMID:  11821279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Decisions concerning the treatment choice for assisted reproduction (IVF or ICSI) are usually made after the evaluation of male fertility factors, or after taking into account the results of previous IVF attempts. There are no widely accepted criteria, so decisions for couples with male subfertility are often empirical and may lead to complete fertilization failure after IVF, or to the unnecessary use of ICSI. METHODS: A study was conducted in which half the oocytes from each of 58 couples with moderate oligo +/- astheno +/- teratozoospermia were inseminated (conventional IVF) and the other half microinjected (ICSI). The technique used for subsequent cycles depended on the results of the first cycle. RESULTS: Nineteen of the 58 IVF/ICSI attempts resulted in fertilization after ICSI only (32.8%) and 39 in fertilization after IVF and ICSI (67.2%). For patients with oocyte fertilization only after ICSI, 61.5% of the oocytes microinjected were fertilized. A mean of 2.2 embryos per patient were transferred, leading to eight clinical pregnancies (42.1%). The implantation rate was 21.4%. All subsequent cycles were carried out with ICSI. Couples with oocyte fertilization after both IVF and ICSI had slightly better semen characteristics than those with oocyte fertilization only after ICSI, but this difference was not significant. Overall, no statistically significant difference was observed between IVF and ICSI in sibling oocytes for any of the variables studied: fertilization rate, embryo morphology and rates of development, pregnancy and implantation. Although only small numbers of oocytes or embryos were available for each couple, six couples had lower fertilization rates after IVF and eight had lower embryo quality after IVF. Eight patients had lower sperm quality in the second cycle, and only seven couples underwent subsequent IVF cycles. CONCLUSIONS: This strategy enabled us to avoid 32.8% of complete fertilization failures after IVF, but not to decrease significantly the number of ICSI attempts in subsequent cycles. However, the uncertainties concerning the safety of ICSI suggest that ICSI should be used cautiously and judiciously.
Authors:
Michelle Plachot; Joëlle Belaisch-Allart; Jean-Marc Mayenga; Albert Chouraqui; Laurent Tesquier; Alain Michel Serkine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  17     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-31     Completed Date:  2002-04-23     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  362-9     Citation Subset:  IM    
Affiliation:
C.H.I. Jean Rostand, 141 Grande Rue, 92310 Sèvres, France. mplachot@maildoc.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Embryo Implantation
Embryo Transfer
Embryo, Mammalian / anatomy & histology,  physiology*
Embryonic and Fetal Development
Female
Fertilization*
Fertilization in Vitro*
Humans
Infertility, Male / therapy*
Male
Oocytes / physiology*
Pregnancy
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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