Document Detail

Outcome of children after maternal primary Toxoplasma infection during pregnancy with emphasis on avidity of specific IgG. The Study Group.
MedLine Citation:
PMID:  7638009     Owner:  NLM     Status:  MEDLINE    
Congenital toxoplasmosis results from maternal primary infection during pregnancy. In our serologic screening study 42 of 16,733 pregnant women had findings suggestive of primary infection. Here we document the outcome of their offspring, 37 of 39 liveborn children. After 12 months postnatally, serologically verified congenital toxoplasmosis appeared in 4 children. All these children had persisting IgG at the age of 12 months by both the dye test and the IgG enzyme-linked immunosorbent assay. All the congenitally infected infants had also specific IgM and IgA and showed significant increases in avidity of specific IgG during the 12-month follow-up. One of them had a unilateral retinal scar and intracranial calcifications. An additional 3 infants of the mothers with primary infection during early pregnancy presented with unilateral retinal scars but without seroresponses during the first 12 months of life. Maternal high avidity of IgG during the first trimester is a strong indicator against primary infection during pregnancy; the fetuses of such mothers are at low risk for congenital toxoplasmosis.
M Lappalainen; M Koskiniemi; V Hiilesmaa; P Ammälä; K Teramo; P Koskela; M Lebech; K O Raivio; K Hedman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  14     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-11     Completed Date:  1995-09-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  354-61     Citation Subset:  IM    
Haartman Institute, Department of Virology, Helsinki, Finland.
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MeSH Terms
Base Sequence
Child, Preschool
Immunoenzyme Techniques
Immunoglobulin G / blood
Infectious Disease Transmission, Vertical*
Molecular Sequence Data
Polymerase Chain Reaction
Pregnancy Complications, Parasitic* / diagnosis,  immunology
Pregnancy Outcome
Prospective Studies
Toxoplasmosis* / diagnosis,  immunology,  transmission
Toxoplasmosis, Congenital* / diagnosis,  immunology,  physiopathology
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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