Document Detail

Outcome of antenatally suspected congenital cystic adenomatoid malformation of the lung: 10 years' experience 1991-2001.
MedLine Citation:
PMID:  16131533     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the outcome of antenatally suspected congenital cystic adenomatoid malformation of the lung (CCAM) over a 10 year period.
METHODS: This is a retrospective study of all babies diagnosed antenatally in the Prenatal Diagnosis Unit and delivered in Oxford between 1991 and 2001. Data were obtained from the Oxford Congenital Anomaly Register, theatre records, and histopathology reports.
RESULTS: Twenty eight cases of CCAM were diagnosed antenatally. Five pregnancies were terminated. Data are available on all 23 of the pregnancies that continued and resulted in two neonatal deaths and 21 surviving babies. Eleven of the 23 cases (48%) showed some regression of the lesion antenatally, and four of these cases appeared to resolve completely on prenatal ultrasound. Three of the 23 babies (13%) were symptomatic in the early neonatal period, and three developed symptoms shortly afterwards. Seventeen of the 23 babies (74%) were asymptomatic, of whom 12 had abnormalities on chest radiograph or computed tomography scan and had elective surgery. Two babies (8%) had completely normal postnatal imaging, and three had abnormalities which resolved in the first year of life. Seventeen of the 23 babies (74%) had surgery. Histology at surgery was heterogeneous. Of the 23 live births, all 21 survivors (91%) are well at follow up or have been discharged.
CONCLUSIONS: All babies diagnosed antenatally with CCAM require postnatal imaging with computed tomography irrespective of signs of antenatal resolution. In asymptomatic infants, the recommendations are close follow up and elective surgery for persistent lesions within the first year of life. Histology at surgery was heterogeneous, and this should be considered when counselling parents.
J K Calvert; P A Boyd; P C Chamberlain; S Syed; S Said; K Lakhoo
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Publication Detail:
Type:  Journal Article     Date:  2005-08-30
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  91     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-22     Completed Date:  2006-01-23     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F26-8     Citation Subset:  AIM; IM    
Neonatal Unit, John Radcliffe Hospital, Oxford OX3 9DU, UK.
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MeSH Terms
Cystic Adenomatoid Malformation of Lung, Congenital / diagnosis*,  radiography,  surgery
Fetal Diseases / diagnosis*
Follow-Up Studies
Infant, Newborn
Long-Term Care / methods
Prenatal Diagnosis*
Retrospective Studies
Comment In:
Arch Dis Child Fetal Neonatal Ed. 2006 Nov;91(6):F463-4   [PMID:  17056845 ]
Arch Dis Child Fetal Neonatal Ed. 2006 Nov;91(6):F464   [PMID:  17056850 ]
Erratum In:
Arch Dis Child Fetal Neonatal Ed. 2006 Jul;91(4):F312
Arch Dis Child Fetal Neonatal Ed. 2006 Jun;91(6):547
Note: Said, S [corrected to Syed, S]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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