Document Detail

Outcome after surgical decompression of severe traumatic brain injury.
MedLine Citation:
PMID:  17081545     Owner:  NLM     Status:  MEDLINE    
One of the factors that affects outcome following severe traumatic brain injury is development and progression of cerebral oedema with associated increase in intracranial pressure (ICP). Uncontrolled elevations of ICP may compromise energy metabolism of the injured brain and lead to secondary injury, affecting neurological outcome of the patient. Decompressive craniectomy has been used for over a century as a treatment of refractory brain swelling in a variety of neurological conditions. However, conclusive evidence of whether it has a beneficial or adverse affect on outcome is lacking. This article reviews the existing evidence on the role of decompressive craniectomy in management of patients with traumatic brain injury and stresses the need for randomised controlled trials.
I Timofeev; P J Hutchinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-11-01
Journal Detail:
Title:  Injury     Volume:  37     ISSN:  0020-1383     ISO Abbreviation:  Injury     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-24     Completed Date:  2007-11-05     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0226040     Medline TA:  Injury     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1125-32     Citation Subset:  IM    
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MeSH Terms
Brain Injuries / complications*,  physiopathology,  surgery
Craniotomy / methods*
Decompression, Surgical / methods*
Glasgow Outcome Scale
Intracranial Pressure
Treatment Outcome
Grant Support
G0601025//Medical Research Council; G9439390//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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