Document Detail

Outcome after pituitary radiosurgery for thalamic pain syndrome.
MedLine Citation:
PMID:  17570607     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate outcomes after pituitary radiosurgery in patients with post-stroke thalamic pain syndrome. METHODS AND MATERIALS: From 2002 to 2006, 24 patients with thalamic pain syndrome underwent pituitary radiosurgery at Tokyo Women's Medical University and were followed at least 12 months thereafter. The radiosurgical target was defined as the pituitary gland and its connection with the pituitary stalk. The maximum dose varied from 140 to 180 Gy. Mean follow-up after treatment was 35 months (range, 12-48 months). RESULTS: Initial pain reduction, usually within 48 h after radiosurgery, was marked in 17 patients (71%). However, in the majority of cases the pain recurred within 6 months after treatment, and at the time of the last follow-up examination durable pain control was marked in only 5 patients (21%). Ten patients (42%) had treatment-associated side effects. Anterior pituitary abnormalities were marked in 8 cases and required hormonal replacement therapy in 3; transient diabetes insipidus was observed in 2 cases, transient hyponatremia in 1, and clinical deterioration due to increase of the numbness severity despite significant reduction of pain was seen once. CONCLUSIONS: Pituitary radiosurgery for thalamic pain results in a high rate of initial efficacy and is accompanied by acceptable morbidity. It can be used as a primary minimally invasive management option for patients with post-stroke thalamic pain resistant to medical therapy. However, in the majority of cases pain recurrence occurs within 1 year after treatment.
Motohiro Hayashi; Mikhail F Chernov; Takaomi Taira; Taku Ochiai; Kotaro Nakaya; Noriko Tamura; Shinichi Goto; Shoji Yomo; Nobuo Kouyama; Yoko Katayama; Yoriko Kawakami; Masahiro Izawa; Yoshihiro Muragaki; Ryoichi Nakamura; Hiroshi Iseki; Tomokatsu Hori; Kintomo Takakura
Related Documents :
20813787 - Conventional and novel biomarkers of treatment outcome in patients with acromegaly: dis...
22613677 - Beneficial effects of non-matched allogeneic cord blood mononuclear cells upon patients...
12118757 - Surgical treatment of pulmonary hydatid cysts: is capitonnage necessary?
1646217 - The endocrine effects of long-term treatment with mifepristone (ru 486).
20505837 - Comparison of clear lens extraction and collamer lens implantation in high myopia.
12892197 - Intramuscular neurilemoma.
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-14
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  69     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2007-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  852-7     Citation Subset:  IM    
Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Follow-Up Studies
Pain, Intractable / surgery*
Pituitary Gland / surgery*
Radiosurgery* / adverse effects
Radiotherapy Dosage
Stroke / complications
Thalamic Diseases / etiology,  surgery*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Phase I trial of tipifarnib (R115777) concurrent with radiotherapy in patients with glioblastoma mul...
Next Document:  Breathing-synchronized delivery: a potential four-dimensional tomotherapy treatment technique.