Document Detail

Outcome after a Pap smear report of low-grade abnormality: a longitudinal comparative study.
MedLine Citation:
PMID:  10554949     Owner:  NLM     Status:  MEDLINE    
The rate of subsequent diagnosis of high-grade cervical abnormality was studied among women whose first Pap smear in 1994 was reported as being negative or from the category of low-grade abnormality (excluding CIN 1). Regardless of the degree of low-grade abnormality reported on the entry smear, the rate of subsequent high-grade disease was 3.3 cases per 100 years of follow-up. The rate of subsequent high-grade disease among women with negative Pap smear reports was 0.23 to 0.45 cases per 100 years of follow-up. Within each cohort, a small number of cases of invasive cervical cancer were diagnosed in the 2 years after the entry smear. These data indicate that Pap smear reports which are coded to the registry squamous cell code of 'mild atypia' (with or without evidence of human papillomavirus effect) have a significantly higher risk of emerging high-grade cervical disease than negative Pap smear reports (including those with minor reactive and/or inflammatory change). It is suggested that the former have a uniform recommendation of repeating the smear in 1 year and the latter in 2 years.
H Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  39     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-12-01     Completed Date:  1999-12-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  345-8     Citation Subset:  IM    
Victorian Cervical Cytology Registry, Melbourne.
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MeSH Terms
Adenocarcinoma / pathology*
Carcinoma, Squamous Cell / pathology*
Cervix Uteri / pathology*
Disease Progression
Prospective Studies
Uterine Cervical Neoplasms / pathology*
Vaginal Smears*
Comment In:
Aust N Z J Obstet Gynaecol. 2000 Nov;40(4):478-9   [PMID:  11194448 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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