Document Detail

Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin.
MedLine Citation:
PMID:  18456443     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the relation between outcome and treatment with steroids and gammaglobulin in children with acute necrotizing encephalopathy. METHODS: We retrospectively evaluated the clinical course and outcome of 34 children with acute necrotizing encephalopathy. They were divided into two groups; 17 patients with brainstem lesion and 17 patients without brainstem lesion. Early steroid use was defined as when steroids were administered within 24h after the onset. The outcome was judged as good when a patient had no or mild cognitive impairment and poor when a patient had more severe sequelae, or died. RESULTS: Among patients without brainstem lesions, the outcome was good in 7 of 12 with early steroid, whereas it was poor in all 5 patients without early steroid. There was no significant difference in sex, age, and laboratory data between patients with and without early steroid. The outcome was not correlated with gammaglobulin treatment. As to patients without brainstem lesions, the outcome was not correlated with early steroid or gammaglobulin treatment. CONCLUSIONS: Steroid within 24 h after the onset was related to better outcome of children with acute necrotizing encephalopathy without brainstem lesions. Early steroid treatment will be an important option of the treatment for acute necrotizing encephalopathy.
Akihisa Okumura; Masashi Mizuguchi; Hiroyuki Kidokoro; Manabu Tanaka; Sinpei Abe; Mitsuaki Hosoya; Hideo Aiba; Yoshihiro Maegaki; Hitoshi Yamamoto; Takuya Tanabe; Eiko Noda; George Imataka; Hirokazu Kurahashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-05
Journal Detail:
Title:  Brain & development     Volume:  31     ISSN:  1872-7131     ISO Abbreviation:  Brain Dev.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
Department of Pediatrics, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
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MeSH Terms
Adrenal Cortex Hormones / administration & dosage,  adverse effects,  therapeutic use*
Brain Diseases / drug therapy*,  mortality,  pathology
Brain Stem / drug effects,  immunology,  pathology
Child, Preschool
Cognition Disorders
Retrospective Studies
Sex Characteristics
Treatment Outcome
gamma-Globulins / therapeutic use*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/gamma-Globulins

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