| Outcome of long-term prophylaxis after cerebral hemorrhage in a patient with severe hemophilia B. | |
| | |
MedLine Citation:
|
PMID: 21078618 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Reports of intracerebral hemorrhage (ICH) in patients with hemophilia B are relatively rare. We describe the first clinical results of the use of a monoclonal antibody purified factor IX (FIX) concentrate (Mononine) after an ICH and the long-term outcome of prophylaxis with this product to prevent recurrences. A 44-year-old male with severe hemophilia B was referred to our department because of nausea, vomiting, left lower limb hemiplegia, and left arm paresis. Computed tomography (CT) revealed a right frontal intraparenchymal bleed. The patient was treated with replacement therapy with FIX for 40 days. Computed tomography scans performed on day 40 after the event showed complete disappearance of the cerebral hematoma from the parenchymal tissue. Subsequently, the patient received 25.6 IU/kg(-1) of FIX twice a week. At the 48-month follow-up visit, no more major or minor bleeding events had occurred. Long-term prophylaxis after ICH is recommended. |
| | |
Authors:
|
Ezio Zanon; Maria Teresa Sartori; Luca Spiezia; Barbara Brandolin; Paolo Simioni; Renzo Manara |
Related Documents
:
|
12228788 - Relationship between activated clotting time during percutaneous intervention and subse... 19660788 - Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase ... 8128328 - The role of endoscopic thrombin injections in the treatment of gastroduodenal bleeding. 10796518 - Antifibrinolytics for heavy menstrual bleeding. 23543398 - Relationship between postoperative clopidogrel use and subsequent angiographic and clin... 8749568 - Immunomodulating effects of synchronised plasmapheresis and intravenous bolus cyclophos... |
Publication Detail:
|
Type: Journal Article Date: 2010-11-15 |
Journal Detail:
|
Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: 17 ISSN: 1938-2723 ISO Abbreviation: Clin. Appl. Thromb. Hemost. Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-09-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: United States |
Other Details:
|
Languages: eng Pagination: 535-8 Citation Subset: IM |
Affiliation:
|
1Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair Internal Medicine University of Padua Medical School, Padua, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coagulation activity in elderly patients with hip fracture measured by prothrombin fragment 1 + 2 in...
Next Document: Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and ...