Document Detail


Outcome of long-term prophylaxis after cerebral hemorrhage in a patient with severe hemophilia B.
MedLine Citation:
PMID:  21078618     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Reports of intracerebral hemorrhage (ICH) in patients with hemophilia B are relatively rare. We describe the first clinical results of the use of a monoclonal antibody purified factor IX (FIX) concentrate (Mononine) after an ICH and the long-term outcome of prophylaxis with this product to prevent recurrences. A 44-year-old male with severe hemophilia B was referred to our department because of nausea, vomiting, left lower limb hemiplegia, and left arm paresis. Computed tomography (CT) revealed a right frontal intraparenchymal bleed. The patient was treated with replacement therapy with FIX for 40 days. Computed tomography scans performed on day 40 after the event showed complete disappearance of the cerebral hematoma from the parenchymal tissue. Subsequently, the patient received 25.6 IU/kg(-1) of FIX twice a week. At the 48-month follow-up visit, no more major or minor bleeding events had occurred. Long-term prophylaxis after ICH is recommended.
Authors:
Ezio Zanon; Maria Teresa Sartori; Luca Spiezia; Barbara Brandolin; Paolo Simioni; Renzo Manara
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Publication Detail:
Type:  Journal Article     Date:  2010-11-15
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  17     ISSN:  1938-2723     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  535-8     Citation Subset:  IM    
Affiliation:
1Department of Cardiologic, Thoracic and Vascular Sciences, 2nd Chair Internal Medicine University of Padua Medical School, Padua, Italy.
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