Document Detail

Outcome of IVF pregnancies following severe OHSS.
MedLine Citation:
PMID:  19573292     Owner:  NLM     Status:  MEDLINE    
Because severe ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening iatrogenic complication, much effort is made to prevent it and the anticipated pregnancy naturally becomes of secondary importance. There are many publications on OHSS, but very few on pregnancy outcomes. This work is to review the effect of OHSS on pregnancy outcome along the pregnancy course. Hospitalized patients with severe OHSS are exposed to several insults that could affect pregnancy outcome in its early stages: the ovarian hyperstimulation for IVF itself, haemodynamic instability that involve haemoconcentration, hypoxia, liver and renal dysfunction, and exposure to high endogenous oestrogens, cytokines, renin, angiotensin and prostaglandins. There is a paucity of data on the relation of OHSS and pregnancy complications. The incidence of multiple pregnancies, gestational diabetes mellitus, placental abruption prematurity and low birthweight is higher in cases of pregnancy complicated by severe OHSS. Therefore, these pregnancies should be considered as high-risk pregnancies, and followed/treated as such. As prevention is the best 'treatment' for OHSS, this may imply the need for more patient-friendly or mild stimulation protocols.
Arieh Raziel; Morey Schachter; Shevah Friedler; Raphael Ron-El
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  19     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-03     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  61-5     Citation Subset:  IM    
IVF Unit, Assaf Harofeh Medical Center, Tel-Aviv University, Zerifin 70300, Israel.
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MeSH Terms
Fertilization in Vitro / adverse effects*
Ovarian Hyperstimulation Syndrome / etiology,  physiopathology*
Pregnancy Outcome*
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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