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Outcome of Down Syndrome associated Acute Lymphoblastic Leukaemia treated on a contemporary protocol.
MedLine Citation:
PMID:  24428704     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report the outcome for children and young people with Down Syndrome-associated Acute Lymphoblastic Leukaemia (DS-ALL) treated on a contemporary protocol. Compared with non-DS ALL, patients with DS-ALL had an inferior event-free survival (65·6% vs. 87·7% at 5 years; P < 0·00005) and overall survival (70·0% vs. 92·2%; P < 0·00005). Excess treatment-related mortality - was primarily responsible for the worse outcomes for DS-ALL (21·6% at 5 years, vs. 3·3%, P < 0·00005). Minimal residual disease (MRD) risk status was highly discriminant for relapse in DS patients with 0/28 relapses in the MRD low risk group.
Authors:
Katharine Patrick; Rachel Wade; Nicholas Goulden; Clare Rowntree; Rachael Hough; Anthony V Moorman; Christopher D Mitchell; Ajay Vora
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-15
Journal Detail:
Title:  British journal of haematology     Volume:  -     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 John Wiley & Sons Ltd.
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