Document Detail

Outcome of 40 adults aged from 18 to 55 years with acute lymphoblastic leukemia treated with double-delayed intensification pediatric protocol.
MedLine Citation:
PMID:  20434771     Owner:  NLM     Status:  MEDLINE    
Adolescents ALL have a better outcome when treated with pediatric protocol compared to adult protocol. We have tested the feasibility of pediatric protocol to treat 40 consecutive adults ALL. DFS and OS were 73±7%, and 72±7%, and were significantly longer in patients under 40 yo (81±9% vs 51±15%, p=0.05 [DFS] and 83±7.8% vs 45±15%, p=0.003 [OS], respectively) or cortico/chemo-sensitive (86±9% vs 36±16%, p=0.001 [DFS] and 95±4.4% vs 28±13%, p<0.0001 [OS]) than in other patients. Overall tolerance was acceptable. We have shown the feasibility of using this unmodified pediatric protocol to treat adult with ALL up to 40 years.
Stéphanie Haïat; Zora Marjanovic; Simona Lapusan; Anne Vekhoff; Bernard Rio; Elise Corre; Sophie Dimicoli; Pierre Hirsch; Jean-Pierre Marie; Ollivier Legrand
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia research     Volume:  35     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Département d'Hématologie Hôpital Hôtel Dieu, AP-HP and Université Pierre et Marie Curie, Paris, France.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  therapeutic use*
Dose-Response Relationship, Drug
Feasibility Studies
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Young Adult

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