| Outbreak of pyogenic abscesses after diphtheria and tetanus toxoids and pertussis vaccination. | |
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MedLine Citation:
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PMID: 8327295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine children who received diphtheria and tetanus toxoids and pertussis vaccine from the same vial at a clinic in Colorado developed pyogenic abscesses at the site of injection. Eight abscesses required surgical drainage and five children were hospitalized. Group A Streptococcus (GAS) was cultured from eight wounds and Staphylococcus aureus was also isolated from four. Epidemiologic investigation revealed that within the hour of the first child's vaccination, three children had been diagnosed in the clinic with GAS pharyngitis. GAS recovered from repeat throat swabs from two of these children and the eight case-isolates were all serotype M-12, T-12 and had identical immunoblot patterns on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Laboratory simulation studies demonstrated that GAS can survive for at least 4 days on the external surface of a vaccine vial rubber stopper and contaminate needles inserted through the stopper. Swabbing the stopper with 70% isopropyl alcohol resulted in effective disinfection. To prevent potential contamination meticulous attention to sterile technique is important when withdrawing vaccine from multidose vaccine vials. |
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Authors:
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P A Simon; R T Chen; J A Elliott; B Schwartz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 12 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-08-12 Completed Date: 1993-08-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 368-71 Citation Subset: IM |
Affiliation:
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Division of Field Epidemiology, Centers for Disease Control and Prevention, Atlanta, GA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Propanol Abscess / epidemiology, etiology*, microbiology Cross Infection / epidemiology, etiology, microbiology Diphtheria-Tetanus-Pertussis Vaccine / adverse effects* Disease Outbreaks* Drug Contamination / prevention & control Humans Infant Pharynx / microbiology Serotyping Specimen Handling / standards Staphylococcal Infections / complications, epidemiology, etiology, microbiology Staphylococcus aureus / isolation & purification Streptococcal Infections / complications, epidemiology, etiology*, microbiology Streptococcus pyogenes* / classification, growth & development, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Diphtheria-Tetanus-Pertussis Vaccine; 71-23-8/1-Propanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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