Document Detail

Outbreak of adenovirus type 30 in a neonatal intensive care unit.
MedLine Citation:
PMID:  15812457     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To describe an outbreak of adenovirus, type 30, in a neonatal intensive care unit (NICU). STUDY DESIGN: This was a retrospective, observational study. RESULTS: An outbreak of adenovirus infection occurred in an NICU. It lasted 6 months and involved 21 of 333 (6.3%) infants. The introduction of infection control measures controlled the outbreak; however, premature discontinuation of the measures resulted in a second wave of cases. The virus caused pneumonia in 7 infants, conjunctivitis in 7 infants, pneumonia and conjunctivitis in 1 infant, and upper respiratory tract illness in 1 infant. Infection was asymptomatic in 5 infants. Six infants died. Death was associated with the presence of pneumonia ( P = .0001), administration of steroids ( P = .003), and mechanical ventilation ( P = .02). Investigation into the origin of the outbreak suggested that the virus may have been introduced and spread during ophthalmologic procedures. CONCLUSIONS: Adenovirus type 30 can cause severe disease among premature infants in an NICU. Infants with severe bronchopulmonary dysplasia requiring mechanical ventilation are more likely to have development of adenovirus pneumonia and die. Standard infection control measures are effective in controlling an outbreak. Ophthalmologic procedures continue to be a potential source of adenovirus outbreaks.
Howard Faden; Ralph J Wynn; Linda Campagna; Rita M Ryan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  146     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-06     Completed Date:  2005-05-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  523-7     Citation Subset:  AIM; IM    
Department of Pediatrics, State University of New York at Buffalo, Women and Children's Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA.
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MeSH Terms
Adenoviridae Infections / epidemiology*,  transmission
Cross Infection / epidemiology*,  transmission
Disease Outbreaks*
Infant, Newborn
Infant, Premature, Diseases / epidemiology*
Infectious Disease Transmission, Professional-to-Patient
Intensive Care Units, Neonatal
Retrospective Studies
Comment In:
J Pediatr. 2005 Apr;146(4):447-8   [PMID:  15812443 ]
J Pediatr. 2005 Apr;146(4):A2   [PMID:  15812439 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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