| Out-of-plane microtube arrays for drug delivery--liquid flow properties and an application to the nerve block test. | |
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MedLine Citation:
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PMID: 19051036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have proposed fabricating very fine out-of-plane silicon-dioxide microtube arrays using a selective vapor-liquid-solid (VLS) growth technique and microfabrication processes. In this study, we elucidated the liquid-flow properties of microtubes with different inner diameters. Our fabricated microtubes were 0.5 microm in wall thickness; 20 microm in height; and either 2.5 microm, 4.1 microm, 4.6 microm, or 6.4 microm in inner diameter. We determined the relationship between the flow pressure and the liquid flow rate through the microtube. We also conducted a nerve block test, in which a microtube with 4.6 microm inner diameter was used to administer lidocaine solution (Na channel blocker) to the rat sciatic nerve. This successful test represents the first reported use of a microtube for drug delivery to the peripheral nerve of a rat. We conclude that the proposed microtube array and its fabrication process might contribute to developing pharmacological devices. |
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Authors:
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Kuniharu Takei; Takahiro Kawashima; Takeshi Kawano; Hidekazu Kaneko; Kazuaki Sawada; Makoto Ishida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomedical microdevices Volume: 11 ISSN: 1572-8781 ISO Abbreviation: Biomed Microdevices Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-04-23 Completed Date: 2009-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100887374 Medline TA: Biomed Microdevices Country: United States |
Other Details:
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Languages: eng Pagination: 539-45 Citation Subset: IM |
Affiliation:
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Department of Electrical and Electronic Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi, 441-8580, Japan. takei@dev.eee.tut.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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administration & dosage,
pharmacology* Animals Drug Delivery Systems* Electrodes Equipment Design Guidelines as Topic Lidocaine / administration & dosage, pharmacology* Male Microscopy, Electron, Scanning Microtechnology* Nerve Block* Peripheral Nerves / drug effects, metabolism Rats Rats, Sprague-Dawley Sciatic Nerve / drug effects, metabolism Silicon Dioxide / chemistry Silver / chemistry Silver Compounds / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Silver Compounds; 137-58-6/Lidocaine; 7440-22-4/Silver; 7631-86-9/Silicon Dioxide; 7783-90-6/silver chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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