| Ouabainlike compound in hypertension associated with ectopic corticotropin syndrome. | |
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MedLine Citation:
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PMID: 8794827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Molecular mechanisms related to sodium retention have been implicated in the pathogenesis of hypertension. It is unclear how sodium retention leads to a rise in blood pressure, but ouabainlike compound may act as a final common pathway in sodium-induced hypertension. In ectopic corticotropin syndrome, hypertension has been attributed to cortisol inactivation overload, giving rise to mineralocorticoid-type hypertension. We sequentially measured plasma and urinary levels of ouabainlike compound over 2 months to evaluate its role in the hypertensive mechanisms in a 64-year-old man with this syndrome caused by lung cancer. His data included hypokalemia and increased cortisol concentrations, corticotropin levels, and urinary 17-hydroxycorticosteroid excretion. Plasma renin activity was suppressed. Plasma and urinary levels of ouabainlike compound were markedly increased concomitantly with high blood pressure. The maximum plasma level was 40-fold the normal range of the subject. After chemotherapy, ouabainlike compound levels gradually decreased in parallel with the decline in blood pressure and rise in potassium concentration. A correlation was observed between plasma and urinary levels of ouabainlike compound (P < .05). Plasma and urinary levels of ouabainlike compound correlated with systolic (P < .01) and diastolic (P < .05) pressures, respectively. The peak of ouabainlike compound in plasma and urine coincided with that of authentic ouabain on high-performance liquid chromatography. Ouabainlike compound derived from urine inhibited [3H]ouabain binding to human erythrocytes. These findings suggest that ouabainlike compound with biological activity could partly account for hypertension in ectopic corticotropin syndrome. |
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Authors:
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A Goto; K Yamada; H Hazama; Y Uehara; K Atarashi; Y Hirata; K Kimura; M Omata |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 28 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-11-22 Completed Date: 1996-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 421-5 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ACTH Syndrome, Ectopic
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blood*,
etiology,
urine* Chromatography, High Pressure Liquid Humans Hypertension / blood*, etiology, urine* Lung Neoplasms / complications Male Middle Aged Ouabain / blood*, urine* |
| Chemical | |
Reg. No./Substance:
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630-60-4/Ouabain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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