| Ouabain, a circulating hormone secreted by the adrenals, is pivotal in cardiovascular disease. Fact or fantasy? | |
| | |
MedLine Citation:
|
PMID: 19050442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Substantial evidence points to the presence in human plasma of an inhibitor of the sodium/potassium pump which plays a central role in the pathophysiology of circulatory disorders, including essential hypertension. Studies from the 1980/90s claimed that this inhibitor was identical or very similar in structure to plant-derived ouabain and was synthesized by the adrenal cortex. However, the physical evidence in studies reporting isolation and identification of ouabain in human plasma appears insecure on closer examination. Additionally, reported circulating levels of immunoreactive ouabain in humans vary greatly, the ability of the human adrenal glands to secrete ouabain is questionable and the original commercial assay for measuring immunoreactive ouabain is no longer available. We submit that the position of ouabain as an endogenous, adrenally produced regulator of the sodium pump is of such importance that the current evidence needs either to put on a more secure footing or to lose its current status. |
| | |
Authors:
|
M Gary Nicholls; Lynley K Lewis; Tim G Yandle; Gwyn Lord; William McKinnon; Philip J Hilton |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of hypertension Volume: 27 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-12-03 Completed Date: 2009-01-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 3-8 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Otago-Christchurch, Christchurch Hospital, Christchurch, New Zealand. gary.nicholls@cdhb.govt.nz |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Glands
/
secretion* Animals Cardenolides / administration & dosage, blood*, isolation & purification Cardiovascular Diseases / etiology* Chromatography, High Pressure Liquid Diet Humans Ouabain / blood*, isolation & purification Saponins / administration & dosage, blood*, isolation & purification Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
|
0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 630-60-4/Ouabain; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Methodological approach to the first and second lactate threshold in incremental cardiopulmonary exe...
Next Document: Endogenous ouabain in cardiovascular function and disease.