Document Detail

Ototoxicity of ototopical antibiotic drops in humans.
MedLine Citation:
PMID:  15054365     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to determine the incidence of injury to the cochlea or vestibular system from the use of ototopic antibiotic ear drops. STUDY DESIGN: We conducted a MEDLINE search of the published literature from 1966 to the present using the search items of "ototopic antibiotics," "ototopic drops," "antibiotic resistance," and others to identify pertinent articles. These articles were reviewed and graded according to evidence quality. Forty-four articles were found; 27 articles were considered appropriate for review and 14 of these articles were thought to warrant further extensive review. The latter 14 articles dealt directly with the evaluation of either hearing loss or changes in vestibular function after the use of ototopic ear drops. We eliminated studies that did not consider hearing or vestibular function. We considered only articles in the English language, eliminating articles that not address the ototoxicity of ototopical ear drops. RESULTS: Most of these articles were in the level 3 to 3b category. Two of the articles were in the 1b category, evaluating evidence-based studies. An article that reviewed case reports of ototopical ototoxicity and a survey article are included in this study, as case reports of ototopical ototoxicity and survey articles. CONCLUSION: We found a total of 54 cases of gentamicin vestibular toxicity and, in 24 of these patients, cochlear toxicity was also documented. Our review also found 11 cases of cochlear and 2 cases of vestibular toxicity in neomycin-based ear drops.
Greg Matz; Leonard Rybak; Peter S Roland; Maureen Hannley; Rick Friedman; Spiros Manolidis; Michael G Stewart; Peter Weber; Fred Owens
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  130     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-31     Completed Date:  2004-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S79-82     Citation Subset:  IM    
Loyola University Medical Center, Chicago, IL 60611, USA.
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MeSH Terms
Administration, Topical
Anti-Bacterial Agents / administration & dosage,  toxicity*
Cochlea / drug effects*
Gentamicins / administration & dosage,  toxicity*
Hearing Loss / diagnosis
Neomycin / administration & dosage,  toxicity
Vestibular Function Tests
Vestibule, Labyrinth / drug effects*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 1404-04-2/Neomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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