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Ototoxic effects of styrene alone or in concert with other agents: A review.
MedLine Citation:
PMID:  12678924     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Styrene is an organic solvent employed in many manufacturing industries, as well as in other economic sectors. Recently, evidence is beginning to accumulate on the hazardous effects that styrene exposures have on the auditory system. In rats, a well-suited metabolic animal model for these studies, aromatic solvents seem to affect the auditory sensitivity mainly in the cochlear mid-frequency range. Outer hair cells are the primary targets within the organ of Corti, although the spiral ganglions are not spared. Therefore, styrene must be considered as an ototoxic chemical agent that can be potentially neurotoxic. Finally, noise-styrene exposures can have synergistic effects on the auditory system. The findings reported in both human and animal studies indicate that exposures to styrene, or to styrene associated to noise, may dramatically impact occupational hearing conservation practices and legislation. Human and animal studies will be summarized in discussing the effects of styrene alone or in combination with noise and other chemicals. Gaps in scientific knowledge are highlighted to assist future research.
Authors:
Thais C. Morata; Pierre Campo
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Noise & health     Volume:  4     ISSN:  1463-1741     ISO Abbreviation:  Noise Health     Publication Date:  2002  
Date Detail:
Created Date:  2003-Apr-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815620     Medline TA:  Noise Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  15-24     Citation Subset:  -    
Affiliation:
National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway/MS:C27 Cincinnati, Ohio 45226-1998, USA., Email: tmorata@cdc.gov
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