Document Detail


Ototoxic drugs: difference in sensitivity between mice and guinea pigs.
MedLine Citation:
PMID:  20015469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of experimental animal models has played an invaluable role in understanding the mechanisms of neurosensory deafness and in devising effective treatments. The purpose of this study was to develop an adult mouse model of ototoxic drug-induced hearing loss and to compare the ototoxicity in the adult mouse to that in the well-described guinea pig model. Mice are a powerful model organism, especially due to the large availability of antibodies, probes and genetic mutants. In this study, mice (n=114) and guinea pigs (n=35) underwent systemic treatment with either kanamycin or cisplatin. Auditory brainstem responses showed a significant threshold shift in guinea pigs 2 weeks after the beginning of the ototoxic treatment, while there was no significant hearing impairment recorded in mice. Hair cells and neuronal loss were correlated with hearing function in both guinea pigs and mice. These results indicate that the mouse is not a good model for ototoxicity, which should be taken into consideration in all further investigations concerning ototoxicity-induced hearing loss.
Authors:
A L Poirrier; P Van den Ackerveken; T S Kim; R Vandenbosch; L Nguyen; P P Lefebvre; B Malgrange
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-14
Journal Detail:
Title:  Toxicology letters     Volume:  193     ISSN:  1879-3169     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Otolaryngology, University Hospital of Li?ge, Li?ge, Belgium. alpoirrier@student.ulg.ac.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / toxicity*
Antineoplastic Agents / toxicity*
Cisplatin / toxicity*
Deafness / chemically induced*,  pathology
Drug Toxicity*
Evoked Potentials, Auditory, Brain Stem / drug effects
Fluorescent Antibody Technique
Guinea Pigs
Hearing / drug effects
Kanamycin / toxicity*
Male
Mice
Mice, Inbred BALB C
Neurons / pathology
Organ of Corti / pathology
Species Specificity
Spiral Ganglion / drug effects,  pathology
Tolonium Chloride
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antineoplastic Agents; 15663-27-1/Cisplatin; 59-01-8/Kanamycin; 92-31-9/Tolonium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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