Document Detail


Otosyphilis in HIV-coinfected individuals: a case series from Toronto, Canada.
MedLine Citation:
PMID:  18290755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to identify and review the clinical features and treatment outcomes of eight recent cases of otosyphilis in HIV-positive patients seen in Toronto. All patients reported tinnitus, and seven (87.5%) reported subjective hearing loss. Not taking auditory findings into consideration, four patients would be classified as having secondary syphilis, three patients as having early latent syphilis, and one patient as having latent syphilis of unknown duration. The median CD4 cell count was 370 x 10(6)/L. All patients were treated with intravenous aqueous penicillin G with regimens recommended for the treatment of neurosyphilis; four patients received adjunctive steroids. All eight patients experienced improvement in tinnitus and four of the seven (57.1%) patients with symptomatic hearing loss also experienced improvement. Otosyphilis can occur in HIV-positive individuals despite high CD4 cell counts, and is potentially reversible. Increased awareness of uncommon manifestations of syphilis in high-risk individuals is warranted to prompt appropriate investigation and treatment.
Authors:
Sharmistha Mishra; Sharon Lynn Walmsley; Mona Rafik Loutfy; Rupert Kaul; Kenneth John Logue; Wayne Lawrence Gold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AIDS patient care and STDs     Volume:  22     ISSN:  1557-7449     ISO Abbreviation:  AIDS Patient Care STDS     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-14     Completed Date:  2008-03-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9607225     Medline TA:  AIDS Patient Care STDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  IM; X    
Affiliation:
Division of Infectious Diseases, University Health Network, Toronto, Canada., Department of Medicine, University of Toronto, Canada. sharmistha.mishra@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Bacterial Agents / therapeutic use
Ear Diseases / complications*,  drug therapy,  physiopathology
Female
HIV Infections / complications*
HIV-1*
Hearing Loss / classification,  drug therapy,  etiology*
Humans
Male
Ontario
Penicillin G Benzathine / therapeutic use
Syphilis / classification,  complications*,  drug therapy
Treatment Outcome
Urban Population
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 1538-09-6/Penicillin G Benzathine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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