| Otoscopic findings in hypercholesterolemic subjects. | |
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MedLine Citation:
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PMID: 20681365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We aimed to verify the extent of a previously cited relationship between tympanosclerosis and atherosclerosis by investigating subjects with dysfunction in lipid metabolism but no clinically apparent symptoms of atherosclerotic disease. METHODOLOGY: Forty hypercholesterolemic patients were submitted to Doppler ultrasound examination of carotid and vertebrobasilar arterial regions; results were matched to otoscopic findings. Otoscopy was performed to evaluate for sclerotic plaques of the tympanic membrane, which represent the most common, clinically non-relevant manifestation of tympanosclerosis. A control group of 41 randomly chosen healthy subjects were also included. RESULTS: Nine (22.5%) of 40 subjects with hypercholesterolemia showed tympanic sclerotic plaques at otoscopy compared to 2 (4.9%) out of 41 control patients. This difference was statistically significant (p = 0.02). An even stronger association (p = 0.01) was found between tympanic and arterial plaques in the study group, as we identified tympanic sclerotic plaques in 7 (41.2%) out of 17 patients with positive Doppler ultrasound signals for arterial plaques. Only two (8.7%) out of 23 subjects without plaques on Doppler ultrasound examination had tympanic sclerotic plaques. CONCLUSIONS: The results of this study confirm the existence of a link between tympanosclerosis and atherosclerosis. To our knowledge, this is the first report of a link between these findings in preclinical atherosclerotic conditions. |
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Authors:
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A Pirodda; C Bruzzi; G G Ferri; G C Modugno; A Gaddi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: B-ENT Volume: 6 ISSN: 1781-782X ISO Abbreviation: B-ENT Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-04 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101247842 Medline TA: B-ENT Country: Belgium |
Other Details:
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Languages: eng Pagination: 123-6 Citation Subset: IM |
Affiliation:
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Department of Specialist Surgical and Anaesthesiological Sciences, ENT Section, S.Orsola-Malpighi University Hospital, Bologna, Italy. antonio.pirodda@unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carotid Arteries / ultrasonography Female Humans Hypercholesterolemia / pathology* Male Middle Aged Otoscopy Sclerosis Tympanic Membrane / pathology* Ultrasonography, Doppler |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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