| Otophyma: a case report and review of the literature of lymphedema (elephantiasis) of the ear. | |
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MedLine Citation:
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PMID: 18212550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phymas (swellings, masses, or bulbs) are considered the end-stage of rosacea and mostly affect the nose (rhinophyma), and rarely involve the chin (gnatophyma), the cheek (metophyma), eyelids (blepharophyma), or ears (otophyma). Herein, we report the case of a 57-year-old man who developed unilateral enlargement of his left ear over 2 years. Biopsy revealed changes of rosaceous lymphedema associated with Demodex infestation. Corticosteroid and minocycline therapies resulted in partial reduction of the ear enlargement. Literature review examining for cases of lymphedema (elephantiasis) of the ear revealed that chronic inflammatory disorders (rosacea (most frequent), psoriasis, eczema), bacterial cellulitis (erysipelas), pediculosis, trauma, and primary (congenital) lymphedema can all lead to localized, lymphedematous enlargement of the ear. Depending on the severity, medical treatment directed at the inflammatory condition for mild, diffuse enlargement to surgical debulking for extensive diffuse enlargement or tumor formation can improve the signs and symptoms of otophyma. Decreased immune surveillance secondary to rosaceous lymphedema may explain why Demodex infestation is common in rosacea and support the suspicion that phymatous skin is predisposed to skin cancer development. |
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Authors:
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J Andrew Carlson; Jill Mazza; Kenneth Kircher; Tien Anh Tran |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 30 ISSN: 1533-0311 ISO Abbreviation: Am J Dermatopathol Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-23 Completed Date: 2008-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Affiliation:
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Division of Dermatology, Albany Medical College, 47 New Scotland Ave., Albany, NY 12208, USA. carlsoa@mail.amc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Alcoholism Anti-Infective Agents / therapeutic use Anti-Inflammatory Agents / therapeutic use Antidepressive Agents, Second-Generation / therapeutic use Antihypertensive Agents / therapeutic use Antilipemic Agents / therapeutic use Dapsone / therapeutic use Doxycycline / therapeutic use Ear Deformities, Acquired / etiology*, metabolism, pathology* Elephantiasis / etiology*, metabolism, pathology* Fluoxetine / therapeutic use Humans Hydrochlorothiazide / therapeutic use Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Hypercholesterolemia / drug therapy Hypertension / drug therapy Insecticides / therapeutic use Male Middle Aged Minocycline / therapeutic use Mite Infestations / pathology Mood Disorders / drug therapy Permethrin / therapeutic use Prednisone / therapeutic use Procetofen / therapeutic use Rosacea / complications*, microbiology, pathology Triamcinolone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Infective Agents; 0/Anti-Inflammatory Agents; 0/Antidepressive Agents, Second-Generation; 0/Antihypertensive Agents; 0/Antilipemic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Insecticides; 10118-90-8/Minocycline; 124-94-7/Triamcinolone; 49562-28-9/Procetofen; 52645-53-1/Permethrin; 53-03-2/Prednisone; 54910-89-3/Fluoxetine; 564-25-0/Doxycycline; 58-93-5/Hydrochlorothiazide; 80-08-0/Dapsone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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