Document Detail

Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up.
MedLine Citation:
PMID:  19609572     Owner:  NLM     Status:  MEDLINE    
GOALS OF WORK: This is a prospective clinical study aimed at assessing the success rate of osteotomy and primary wound closure in patients with bisphosphonate-associated osteonecrosis of the jaw (BONJ). MATERIALS AND METHODS: Fifty patients who had received bisphosphonates intravenously and subsequently suffered from BONJ were included in the study. All patients underwent osteotomy of the affected jaw bone region and primary wound closure under general anaesthesia. They were followed up bimonthly for a period of 12 months. RESULTS: Macroscopically altered bone could be completely removed in all cases. In two patients with plasmocytoma, major bleeding occurred postoperatively that required monitoring in an intensive care unit. In two cases, recurrence of BONJ was diagnosed during the first 2 months. In three patients, recurrence appeared between the fourth and the sixth month. In these cases, an additional osteotomy had to be performed. Six patients died during the follow-up period. In the remaining 39 patients, no signs of recurrence could be detected during the follow-up of 12 months. The success rate of the surviving patients was 89% after 1 year. CONCLUSION: Due to the high success rate of osteotomy and primary wound closure, it should be checked for every patient suffering from BONJ if osteotomy is a viable treatment option.
Philipp Stockmann; Eleftherios Vairaktaris; Falk Wehrhan; Martin Seiss; Stephan Schwarz; Bernd Spriewald; Friedrich-Wilhelm Neukam; Emeka Nkenke
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-07-17
Journal Detail:
Title:  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     Volume:  18     ISSN:  1433-7339     ISO Abbreviation:  Support Care Cancer     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-02     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302957     Medline TA:  Support Care Cancer     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  449-60     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Friedrich-Alexander University Erlangen-Nuremberg, Gl?ckstrasse 11, 91054 Erlangen, Germany.
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MeSH Terms
Aged, 80 and over
Bone Density Conservation Agents / adverse effects,  therapeutic use
Diphosphonates / adverse effects*,  therapeutic use
Follow-Up Studies
Jaw Diseases / chemically induced,  surgery*
Middle Aged
Osteonecrosis / chemically induced,  surgery*
Osteotomy / methods*
Plasmacytoma / complications
Prospective Studies
Suture Techniques
Treatment Outcome
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates

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