| Osteosarcoma associated with absent thumbs: a report of two cases. | |
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MedLine Citation:
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PMID: 10695826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An 8-year-old Hispanic boy with a hypoplastic left thumb, absent right thumb, and short stature experienced right leg pain and limp. A right tibial lesion was imaged and found to be osteosarcoma on biopsy. A 6-year-old Hispanic girl with congenitally absent thumbs experienced a pathologic fracture of her left femur after a minor sports injury. The radiologic abnormality seen was diagnosed as osteosarcoma on biopsy. Both patients continue to do well after intensive preoperative and postoperative high-dose chemotherapy and definitive reconstructive limb surgery. Osteosarcoma has been linked to several congenital syndromes in which absent thumbs are a feature. These two patients with absent thumbs and no definable syndrome experiencing osteosarcoma suggest that congenitally absent thumbs might be a risk factor for osteosarcoma in the absence of a syndrome. |
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Authors:
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L Orme; R Gorlick; P A Meyers; E Athanasian; A G Huvos |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 22 ISSN: 1077-4114 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2000 Jan-Feb |
Date Detail:
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Created Date: 2000-03-22 Completed Date: 2000-03-22 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 73-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Neoplasms*
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etiology Child Female Hand Deformities, Congenital* / etiology Humans Male Osteosarcoma* / etiology Risk Factors Thumb / abnormalities* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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