Document Detail


Osteosarcoma and acromegaly: a case report and review of the literature.
MedLine Citation:
PMID:  17259799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 72-yr-old acromegalic man, who presented with pain in the left femur, was found to have a metastatic osteosarcoma. Only three cases describing the coexistence of acromegaly and osteosarcoma have been reported by the literature. As the patient didn't have other risk factors for osteosarcoma, the hypothesis that accelerated rate of bone turnover caused by long-term exposure to high GH and IGF-I could act as a predisposing factor in the development of this malignant bone tumor is discussed.
Authors:
G A B Lima; E M S Gomes; R C Nunes; L Vieira Neto; A P A V Sieiro; E P Brabo; M R Gadelha
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  29     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1006-11     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Department of Internal Medicine, Clementino Fraga Filho University Hospital/Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Acromegaly / complications*
Aged
Bone Neoplasms / secondary
Fatal Outcome
Femoral Neoplasms / etiology*
Humans
Male
Osteosarcoma / etiology*,  secondary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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