Document Detail


Osteoprotegerin Levels Change During STEMI and Reflect Cardiac Function.
MedLine Citation:
PMID:  25475457     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: High levels of circulating osteoprotegerin (OPG) predicts long-term outcome in patients with ST-elevation myocardial infarction (STEMI), possibly because of increased vascular inflammation resulting in myocardial damage. In the present study we aimed at elucidating the dynamic progress of OPG levels during STEMI treated with percutaneous coronary intervention (PCI) and additionally, the effect of OPG levels on cardiac function.
METHODS: We prospectively included 42 patients with STEMI treated with primary PCI. Four consecutive blood samples were obtained before and after PCI treatment. Plasma OPG levels were determined using an in-house immunoassay. Cardiac function was increased according to echocardiography, estimating left ventricular ejection fraction (LVEF) 1-3 days after STEMI.
RESULTS: During STEMI, OPG levels peaked after PCI and then decreased; mean concentrations (95% confidence interval) before PCI, after PCI, and on day 1 and day 2 of 2650 ng/L (2315-3036 ng/L), 2778 ng/L (2442-3363 ng/L), 2024 ng/L (1775-230 6ng/L), and 1808 ng/L (1551-2106 ng/L), respectively (P < 0.001). Interestingly, the OPG response was observed before the response in troponin I and C-reactive protein. Patients with reduced LVEF (< 40%) exhibited an increased OPG response before, during, and after PCI (mean increase, 38%; 9%-75%; repeated measures analysis of variance, P = 0.009). Adjustment for age, sex, body mass index, and cardiovascular risk factors did not significantly affect the association between reduced LVEF and increased OPG response (mean increase 33% (4%-70%; F = 5.784; P = 0.023).
CONCLUSIONS: Circulating OPG levels are altered during STEMI treated with primary PCI. A high OPG level is independently associated with impaired LVEF.
Authors:
Søren Lindberg; Jan S Jensen; Søren Hoffmann; Allan Z Iversen; Sune H Pedersen; Rasmus Mogelvang; Søren Galatius; Allan Flyvbjerg; Mette Bjerre
Related Documents :
25494017 - Neural mechanisms and delayed gastric emptying of liquid induced through acute myocardi...
16056207 - Morphometric study of atrioventricular orifices of postmortem hearts of adult banglades...
19521927 - Comparison of initial evaluation of neonatal heart murmurs by pediatrician and pediatri...
7645747 - Swine hearts: quantitative anatomy of the right ventricle.
19652087 - Sirolimus-eluting stent treatment at high-volume centers confers lower mortality at 6-m...
19684037 - Autopsy and clinical context in deceased patients with implanted pacemakers and defibri...
Publication Detail:
Type:  Journal Article     Date:  2014-08-23
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  30     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1523-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Obstructive Sleep Apnea as a Predictor of Atrial Fibrillation After Coronary Artery Bypass Grafting:...
Next Document:  Residual arrhythmogenic foci predict recurrence in long-standing persistent atrial fibrillation pati...